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Five New Secondary Metabolites Produced by a Marine-Associated Fungus, Daldinia eschscholzii

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China [3]Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

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关键词： marine-associated fungus Daldinia eschscholzii secondary metabolites hydrolysis GC analysis X-ray diffraction analysis

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Five new compounds, including a benzopyran ribonic glycoside, daldiniside A (1), two isocoumarin ribonic glycosides, daldinisides B (2) and C (3), and two alkaloids, 1-(3-indolyl)-2R,3-dihydroxypropan-1-one (4) and 3-ethyl-2, 5-pyrazinedipropanoic acid (5), along with five known compounds (6-10), were isolated from the EtOAc extract of the marine-associated fungus, Daldinia eschscholzii. Their structures were elucidated by extensive physicochemical and spectroscopic properties, besides comparison with literature data. The absolute configurations of compounds 1-3 were corroborated by chemical transformation, GC analysis and X-ray crystallographic analysis. Meanwhile, the absolute configuration of compound 4 and the planar structure of compound 6 were also determined based on the X-ray diffraction analysis. The cytotoxicity of compounds 1-10, antifungal and anti-HIV activities of compounds 1-5 and the in vitro assay for glucose consumption of compounds 1-3 were done in the anti-diabetic model, whereas none showed obvious activity.

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出版当年[2013]版：

大类 | 2 区医学

小类 | 2 区药物化学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药物化学 2 区药学

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出版当年[2012]版：

Q1 CHEMISTRY, MEDICINAL

最新[2023]版：

Q1 CHEMISTRY, MEDICINAL Q1 PHARMACOLOGY & PHARMACY

影响因子： 4.9 最新[2023版] 5.2 最新五年平均 3.978 出版当年[2012版] 3.911 出版当年五年平均 3.854 出版前一年[2011版] 3.512 出版后一年[2013版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

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