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New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Deng,Mengyi[1] * ; Tan,Xiaosheng[2,4,5,6] * ; Qiao,Yuben[1] ; Sun,Weiguang[1] ; Xie,Shuangshuang[1] ; Shi,Zhengyi[1] ; Lu,Yuanyuan[3] ; Chen,Gang[2] ; Qi,Changxing[1] ; Zhang,Yonghui[1] ;
单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Inst Organ Transplantat, Tongji Med Coll, Wuhan, Hubei, Peoples R China [3]Huazhong Univ Sci & Technol, Maternal & Child Hlth Hosp Hubei Prov, Tongji Med Coll, Wuhan, Hubei, Peoples R China [4]Minist Educ, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China [5]NHC Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China [6]Chinese Acad Med Sci, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China
出处：
DOI： 10.1080/14786419.2020.1868464
ISSN：

关键词： Aspergillus sp meroterpenoids lovastatin analogues immunosuppressive activity

摘要：
One new 3,5-dimethylorsellinic acid (DMOA)-based meroterpenoid (1), one prenylated tryptophan derivative (2), together with ten known compounds (3-12) were isolated from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii. Their structures and absolute configurations were determined by NMR spectroscopic data, HRESIMS data, UV and IR data as well as electronic circular dichroism (ECD) calculation. In structure, compound 1 was a rare example of DMOA-based meroterpenoid with a cis-fused C/D ring system, and compound 2 possessed an unusual (E)-oxime group. In bioactivity, the lovastatin analogues 5, 6, 9 and 10 showed potential immunosuppressive activity against anti-CD3/anti-CD28 monoclonal antibodies (mAbs)-irritated murine splenocytes proliferation, with IC50 values ranging from (5.30 +/- 0.51) mu M to (16.51 +/- 1.62) mu M.

基金：
Innovative Research Groups of the National Natural Science Foundation of China [81721005]; National Natural Science Foundation for Distinguished Young Scholars [81725021]; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST); Graduates' Innovation Fund of Huazhong University of Science and Technology [2019ygscxcy055]; National Science and Technology Project of China [2018ZX09201001-001-003]; Academic Frontier Youth Team of HUST [2017QYTD19]; Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]; National Natural Science Foundation of China [82003633, 31700294]
语种：
外文
被引次数：
WOS：
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 化学
小类 | 3 区 应用化学 3 区 药物化学
最新[2025]版：
大类 | 3 区 化学
小类 | 3 区 应用化学 4 区 药物化学
JCR分区：
出版当年[2020]版：
Q2 CHEMISTRY, APPLIED Q3 CHEMISTRY, MEDICINAL
最新[2023]版：
Q3 CHEMISTRY, APPLIED Q3 CHEMISTRY, MEDICINAL

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan, Hubei, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Deng Mengyi,Tan Xiaosheng,Qiao Yuben,et al.New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii[J].NATURAL PRODUCT RESEARCH.2022,36(14):3544-3552.doi:10.1080/14786419.2020.1868464.
APA：
Deng,Mengyi,Tan,Xiaosheng,Qiao,Yuben,Sun,Weiguang,Xie,Shuangshuang...&Zhang,Yonghui.(2022).New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii.NATURAL PRODUCT RESEARCH,36,(14)
MLA：
Deng,Mengyi,et al."New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii".NATURAL PRODUCT RESEARCH 36..14(2022):3544-3552

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