单位：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China[2]Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, People’s Republic of China华中科技大学同济医学院附属同济医院器官移植研究所器官移植[3]Hubei Key Laboratory of Wudang Local Chinese Medicine Research, Hubei Engineering Technology Center for Comprehensive Utilization of Medicinal Plants, College of Pharmacy Hubei University of Medicine, Shiyan 442000, People’s Republic of China
Three previously undescribed compounds, including a meroterpenoid, guignardone T (1), and two ophiobolintype sesterterpenoids, maydispenoids A and B (2 and 3), along with four known compounds (4-7), were isolated from the phytopathogenic fungus Bipolaris maydis collected from Anoectochilus roxburghii (Wall.) Lindl leaves. The structures of all undescribed compounds were elucidated by spectroscopic analysis, electronic circular dichroism (ECD) calculations and single-crystal X-ray diffraction. Structurally, maydispenoids A was characterized by a fascinating decahydro-3-oxacycloocta[cd]pentalene fragment. It is notable that the compounds 2 and 3 exhibited potential inhibitory activity in anti-CD3/anti-CD28 monoclonal antibodies (mAbs) stimulated murine splenocytes proliferation, with IC50 values of 5.28 and 9.38 mu M, respectively, and also suppress the murine splenocytes proliferation activated by lipopolysaccharide (LPS), with IC50 values of 7.25 and 16.82 mu M, respectively. This is the first report of ophiobolin-type sesterterpenoids as immunosuppressor, and may provide new chemical templates for the development of new immunosuppressive drugs for autoimmune disease treatment.
基金：
Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21702067, 81573316, 81801587, 31870326, 81602986]; National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [81725021]; Innovative Research Groups of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81721005]
第一作者单位：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China
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推荐引用方式(GB/T 7714)：
duan xueyan,tan xiaosheng,gu lianghu,et al.New secondary metabolites with immunosuppressive activity from the phytopathogenic fungus Bipolaris maydis[J].BIOORGANIC CHEMISTRY.2020,99:doi:10.1016/j.bioorg.2020.103816.
APA：
duan,xueyan,tan,xiaosheng,gu,lianghu,liu,junjun,hao,xincai...&zhang,yonghui.(2020).New secondary metabolites with immunosuppressive activity from the phytopathogenic fungus Bipolaris maydis.BIOORGANIC CHEMISTRY,99,
MLA：
duan,xueyan,et al."New secondary metabolites with immunosuppressive activity from the phytopathogenic fungus Bipolaris maydis".BIOORGANIC CHEMISTRY 99.(2020)
