详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Discovery of immunosuppressive Lupane-type Triterpenoids from Hypericum longistylum

76| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan, Peoples R China [2]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Inst Organ Transplantat,Wuhan,Hubei,Peoples R China [3]Chinese Acad Med Sci, Key Lab Organ Transplantat, Minist Educ, Wuhan, Hubei, Peoples R China [4]Chinese Acad Med Sci, NHC Key Lab Organ Transplantat, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China

出处：

DOI：

ISSN：

关键词： Hypericum longistylum bioassay-directed isolation lupane-type triterpenoid immunosuppressive activity

摘要：

The phytochemistry study of Hypericum longistylum afforded one new degraded lupane-type triterpenoid, triterhyper A (1), and seven known congeners (2-8). The structures of those natural products were identified by extensive spectroscopic techniques and single crystal diffraction tests. Notably, triterhyper A (1) possessing an unusual 28-nor-lupane skeleton. More significantly, compounds 1-3 exhibited potential inhibitory effects on murine splenocytes proliferation stimulated by anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and lipopolysaccharide (LPS), with IC50 values ranging from (4.56 +/- 0.45) mu M to (18.34 +/- 2.34) mu M, highlighting that those isolates as potential lead compounds in the development of immunosuppressive drugs for autoimmune disease treatment.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2021]版：

大类 | 3 区化学

小类 | 3 区应用化学 3 区药物化学

最新[2025]版：

大类 | 3 区化学

小类 | 3 区应用化学 4 区药物化学

JCR分区：

出版当年[2020]版：

Q2 CHEMISTRY, APPLIED Q3 CHEMISTRY, MEDICINAL

最新[2023]版：

Q3 CHEMISTRY, APPLIED Q3 CHEMISTRY, MEDICINAL

影响因子： 1.9 最新[2023版] 2.1 最新五年平均 2.862 出版当年[2020版] 2.572 出版当年五年平均 2.158 出版前一年[2019版] 2.488 出版后一年[2021版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan, Peoples R China

通讯作者：

通讯机构： [2]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Inst Organ Transplantat,Wuhan,Hubei,Peoples R China [3]Chinese Acad Med Sci, Key Lab Organ Transplantat, Minist Educ, Wuhan, Hubei, Peoples R China [4]Chinese Acad Med Sci, NHC Key Lab Organ Transplantat, Key Lab Organ Transplantat, Wuhan, Hubei, Peoples R China

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Bioassay-Directed Isolation of Antibacterial Metabolites from an Arthropod-Derived Penicillium chrysogenum [2]Prenyllongnols A-D, New Prenylated Acylphloroglucinols that Fight Concanavalin A-Induced Autoimmune Hepatitis [3]Alkaloids with Immunosuppressive Activity from the Bark of Pausinystalia yohimbe [4]New secondary metabolites with immunosuppressive activity from the phytopathogenic fungus Bipolaris maydis [5]Ergosterols with rare peroxide, oxetane ring moiety, and a lactone ring from Aspergillus spectabilis and their immunosuppressive activities [6]New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii [7]New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii [8]Structurally diverse and bioactive alkaloids from an insect-derived fungus Neosartorya fischeri [9]New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii [10]Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus