(+/-)-Japonicols A D (1a/1b-4a/4b), four pairs of new phloroglucinol-based terpenoid enantiomers, were isolated from Hypericum japonicum. Their absolute configurations were confirmed through comparison of their experimental and calculated electronic circular dichroism spectra and single -crystal X-ray diffraction analyses. Compounds 1a/1b, 2a/2b, and 3a/ 3b possess 2-oxabicyclo[3.3.1]nonane, pyrano[3,2-b]pyran, and benzo[b]cyclopenta[e]oxepine ring systems, respectively. The effects of the phloroglucinols on anti-Kaposi's sarcoma -associated herpesvirus were assessed, and 2a exhibited a moderate inhibitory effect, with an EC50 value of 8.75 mu M and a selectivity index of 16.06.
基金：
Program for New Century Excellent Talents in University; State Education Ministry of China [2008-0224]; National Natural Science Foundation of China [81573316, 31200258, 21502057, 31500281]
第一作者单位：[1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Wuhan 430030, Hubei Province, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Linzhen,Xue Yongbo,Zhang Jinwen,et al.(±)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum[J].JOURNAL OF NATURAL PRODUCTS.2016,79(5):1322-1328.doi:10.1021/acs.jnatprod.5b01119.
APA：
Hu, Linzhen,Xue, Yongbo,Zhang, Jinwen,Zhu, Hucheng,Chen, Chunmei...&Zhang, Yonghui.(2016).(±)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum.JOURNAL OF NATURAL PRODUCTS,79,(5)
MLA：
Hu, Linzhen,et al."(±)-Japonicols A-D, Acylphloroglucinol-Based Meroterpenoid Enantiomers with Anti-KSHV Activities from Hypericum japonicum".JOURNAL OF NATURAL PRODUCTS 79..5(2016):1322-1328
