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Discovery of ergosterol derivative from Aspergillus sp. TJ507 that protects against hepatic ischemia/reperfusion injury

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收录情况： ◇ SCIE

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单位： [1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China. [2]Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,People's Republic of China. [3]Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Key Laboratory of Organ Transplantation,Ministry of Education,NHC Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Wuhan 430030,Hubei Province,People's Republic of China.

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关键词： Aspergillus sp Sterides Anti-hypoxia injury activities Hepatic ischemia/reperfusion injury

摘要：

Hepatic ischemia/reperfusion injury is a major cause of hypohepatia after surgical procedures such as hypovolemic shock, transplantation, and so on. In our continuous study of bioactive natural products from fungus, eight ergosterol-type sterides (1-8), including two undescribed compounds, sterolaspers A (1) and B (2), were isolated from Aspergillus sp. TJ507. Structure elucidation was accomplished by extensive spectroscopic analysis and comparison with the reported NMR data as well as X-Ray single crystal diffraction tests. Activity screen of these isolates showed 5α-stigmast-3,6-dione (3) possessing anti-hypoxia injury effects against CoCl2-induced hypoxia damage in hepatocytes. More importantly, compound 3 could improve liver function, alleviate liver damage, and restrain the hepatocellular apoptosis in hepatic ischemia/reperfusion injury murine model. As such, this ergosterol-type steride, 5α-stigmast-3,6-dione (3), might serve as lead structure for the development of novel hepatoprotective agents in the clinical treatment of hepatic ischemia/reperfusion injury.Copyright © 2023. Published by Elsevier Inc.

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出版当年[2022]版：

大类 | 1 区

化学

小类 | 1 区有机化学 2 区生化与分子生物学

最新[2025]版：

大类 | 2 区医学

小类 | 1 区有机化学 2 区生化与分子生物学

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出版当年[2021]版：

Q1 CHEMISTRY, ORGANIC Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, ORGANIC

影响因子： 4.5 最新[2023版] 4.7 最新五年平均 5.307 出版当年[2021版] 5.321 出版当年五年平均 5.275 出版前一年[2020版] 5.1 出版后一年[2022版]

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第一作者单位： [1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.

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