Five new acetylenic phenol derivatives (1-4 and 7), one new benzofuran derivative (8), one new naphthol derivative (9), and two known analogues (5 and 6), were isolated and identified from an endophytic fungus Daldinia sp. TJ403-LS1 that was isolated from the medicinally valuable plant Anoectochilus roxburghii. Their structures were elucidated by means of extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. In addition, compound 1 exhibited remarkable immunosuppressive activity against LPS and antiCD3/anti-CD28 mAbs activated murine splenocytes proliferation with the same IC50 values of 0.06 mu M and BChE inhibitory activity with an IC50 value of 6.93 +/- 0.71 mu M, and compounds 6, 8 and 9 showed excellent BChE inhibitory activity with IC50 values of 16.00 +/- 0.30, 23.33 +/- 0.55, and 15.53 +/- 0.39 mu M, respectively (positive drug neostigmine, IC50 = 49.60 +/- 6.10 mu M), highlighting the promising potentials to be designed and developed as immunosuppressive and BChE inhibitory agents.
基金：
National Natural Science Foundation [81725021]; Innovative Research Groups of the National Natural Science Foundation of China [81721005]; National Natural Science Foundation of China [21702067, 81573316]; Tongji-Rongcheng Center for Biomedicine, Huazhong University of Science and Technology [0231514141]; Research and Development Program of Hubei Province [2020BCA058]; Hubei Provincial Natural Science Foundation of China [2019CFB646]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Lin Shuang,Yan Shan,Liu Yi,et al.New secondary metabolites with immunosuppressive and BChE inhibitory activities from an endophytic fungus Daldinia sp. TJ403-LS1[J].BIOORGANIC CHEMISTRY.2021,114:doi:10.1016/j.bioorg.2021.105091.
APA：
Lin, Shuang,Yan, Shan,Liu, Yi,Zhang, Xueke,Cao, Fei...&Zhang, Yonghui.(2021).New secondary metabolites with immunosuppressive and BChE inhibitory activities from an endophytic fungus Daldinia sp. TJ403-LS1.BIOORGANIC CHEMISTRY,114,
MLA：
Lin, Shuang,et al."New secondary metabolites with immunosuppressive and BChE inhibitory activities from an endophytic fungus Daldinia sp. TJ403-LS1".BIOORGANIC CHEMISTRY 114.(2021)
