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Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn

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收录情况： ◇ SCIE

作者：
Zhu, Hucheng[1] * ; Chen, Chunmei[1] ; Liu, Junjun[1] ; Sun, Bin[1] ; Wei, Guangzheng[1] ; Li, Yan[2] ; Zhang, Jinwen[3] ; Yao, Guangmin[1] ; Luo, Zengwei[1] ; Xue, Yongbo[1] ; Zhang, Yonghui[1] ;
单位： [1]Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China [2]Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
出处：
DOI： 10.1016/j.phytochem.2015.02.009
ISSN：

关键词： Hypericum ascyron Linn Hypericaceae Polycyclic polyprenylated acylphloroglucinols Polyprenylated spirocyclic acylphloroglucinol derivatives Cytotoxic activities Anti-HIV-1 activities

摘要：
Eight polyprenylated spirocyclic acylphloroglucinol derivatives (PSAPs), hyperascyrones A-H, were isolated from the aerial parts of Hypericum ascyron Linn., together with six known analogs. Their structures were established by spectroscopic analyses including HRESIMS, 1D and 2D NMR, and their absolute configurations were determined by electronic circular dichroism calculations (ECD, Gaussian 09). Structures of previously reported tomoeones C, D, G, and H were revised. Hyperascyrones A-H were evaluated for their cytotoxic and anti-HIV-1 activities, with hyperascyrones C and G exhibiting significant cytotoxicities against HL-60 cell lines with IC50 values of 4.22 and 8.36 mu M, respectively. In addition, the chemotaxonomic significance of these compounds was also discussed. (C) 2015 Elsevier Ltd. All rights reserved.

基金：
National Natural Science Foundation of China [31370372, 81202423, 31200258]; New Century Excellent Talents in University, State Education Ministry of China [NCET-2008-0224]
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外文
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出版当年[2014]版：
大类 | 3 区 生物
小类 | 2 区 植物科学 3 区 生化与分子生物学
最新[2025]版：
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 植物科学
JCR分区：
出版当年[2013]版：
Q1 PLANT SCIENCES Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版：
Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Q2 PLANT SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhu Hucheng,Chen Chunmei,Liu Junjun,et al.Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn[J].PHYTOCHEMISTRY.2015,115:222-230.doi:10.1016/j.phytochem.2015.02.009.
APA：
Zhu, Hucheng,Chen, Chunmei,Liu, Junjun,Sun, Bin,Wei, Guangzheng...&Zhang, Yonghui.(2015).Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn.PHYTOCHEMISTRY,115,
MLA：
Zhu, Hucheng,et al."Hyperascyrones A-H, polyprenylated spirocyclic acylphloroglucinol derivatives from Hypericum ascyron Linn".PHYTOCHEMISTRY 115.(2015):222-230

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