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One new spirocyclic lactone and one new benzopyran derivative from Aspergillus terreus

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单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Peoples R China [2]Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Dept Pharm, Tongji Med Coll, Wuhan 430030, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China

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关键词： Aspergillus terreus spirocyclic lactone cytotoxic activities

摘要：

One new spirocyclic lactone, terreinlactone C (1), and one new benzopyran derivative, 2,2-dimethyl-3-hydroxychroman-6-aldehyde (2), were discovered from the fungus Aspergillus terreus. The chemical structures of compounds 1 and 2 were elucidated by detailedly analyzing NMR and HRESIMS data. Compound 1 is the first natural product with a 1-oxaspiro[4.5]decan-2-one ring system and a possible biogenetic pathway is proposed. Two compounds were tested for their cytotoxic activities against five human cancer cell lines. [GRAPHICS] .

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出版当年[2020]版：

大类 | 4 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区应用化学 4 区药物化学 4 区药学 4 区植物科学

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出版当年[2019]版：

Q3 PLANT SCIENCES Q3 CHEMISTRY, APPLIED Q4 CHEMISTRY, MEDICINAL Q4 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q3 CHEMISTRY, APPLIED Q3 PLANT SCIENCES Q4 CHEMISTRY, MEDICINAL Q4 PHARMACOLOGY & PHARMACY

影响因子： 1.3 最新[2023版] 1.5 最新五年平均 1.345 出版当年[2019版] 1.237 出版当年五年平均 1.17 出版前一年[2018版] 1.571 出版后一年[2020版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430030, Peoples R China

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