Brasilanones A-F and asperterreusines A-C, undescribed brasilane sesquiterpenoids and dihydrobenzofuran derivatives, were isolated from the marine-derived fungus Aspergillus terreus [CFCC 81836]. Their structures with absolute configurations were elucidated on the basis of spectroscopic data, X-ray crystallographic analyses, and electronic circular dichroism (ECD) calculations. Brasilanones A-F are unusual brasilane sesquiterpenoids with an alpha,beta-unsaturated ketone unit, interestingly, brasilanones B-D are stereo isomers. All of the isolates were evaluated for their inhibitory activities against NO production and cytotoxic activities against five human cancer cell lines (HL-60, SW-480, A-549, MCF-7, and SMMC-7721). Brasilanones A and E showed moderate inhibitory effect with NO inhibition rates of 47.7% (p < 0.001) and 37.3% (p < 0.001) at the concentration of 40 mu M. Asperterreusines A showed cytotoxicity against HL-60 and SW-480 cell lines with IC50 values of 15.3 and 25.7 mu M, respectively.
基金：
Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]; National natural Science Foundation for Distinguished Young Scholars [81725021]; National Science and Technology Project of China [2018ZX09201001-001-003]; Innovative Research Groups of the National Natural Science Foundation of China [81721005]; National Natural Science Foundation of China [81502943, 31600266]; Academic Frontier Youth Team of HUST; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST)
