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Three new Furano-lactones from the endophytic fungus Aspergillus nidulans

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单位： [1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China. [2]Department of Pharmacy, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China. [3]Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

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关键词： Aspergillus nidulans Endophytic fungus Furano-lactones Cytotoxic activities

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Three new furano-lactones, asperilactones A-C (1-3), and two known compounds silvaticol (4) and violaceic acid (5) were isolated from an ethanol extract of Aspergillus nidulans, a fungus isolated from the Annelida Whitmania pigra Whitman (Haemopidae). Their structures were elucidated by a combination of spectroscopy, ECD calculations, comparing optical rotation values, and single-crystal X-ray diffraction analyses. Asperilactone A (1) represented the first example of furano-lactone with an unusual 2-thia-6-oxabicyclo[3.3.0]octane ring system. Asperilactones A and B showed weak toxicity against the HL-60 and RKO.Copyright © 2023. Published by Elsevier B.V.

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出版当年[2023]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区药物化学 3 区药学

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出版当年[2022]版：

Q2 PHARMACOLOGY & PHARMACY Q3 CHEMISTRY, MEDICINAL

最新[2023]版：

Q3 CHEMISTRY, MEDICINAL Q3 PHARMACOLOGY & PHARMACY

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 3.4 出版当年[2022版] 3.3 出版当年五年平均 3.204 出版前一年[2021版] 2.5 出版后一年[2023版]

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第一作者单位： [1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.

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