单位：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.[2]Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.华中科技大学同济医学院附属同济医院器官移植研究所器官移植[3]Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan 430030, People's Republic of China.[4]NHC Key Laboratory of Organ Transplantation, Wuhan 430030, People's Republic of China.[5]Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, People's Republic of China
Hypersonins A-D (1-4), four 1,2-seco-homoadamantane type polycyclic polyprenylated acylphloroglucinols (PPAPs) possessing a new bicyclo[4.3.1]decane-3-methoxycarbonyl architecture, were obtained from Hypericum wilsonii. The structures of hypersonins A-D were identified by spectroscopic data, electronic circular dichroism comparison, and X-ray crystallographic data. Hypersonins A-D are the first seco-homoadamantane-type PPAPs with cleavage at the C-1-C-2 bond. Hypersonin A (1) showed moderate inhibitory activity to anti-CD3/anti-CD28 monoclonal antibody-induced proliferation of murine splenocytes, with an IC50 value of 8.3 +/- 0.2 mu M.
基金：
Innovative Research Groups of the NSFCNational Natural Science Foundation of China (NSFC) [81721005]; NSFDYS [81725021]; National Science and Technology Project of China [2018ZX09201001-001-003]; Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]; Health Commission of Hubei Province [WJ2019Q007]; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST); Wuhan HPC [WX17Q34]
第一作者单位：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
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推荐引用方式(GB/T 7714)：
xie shuangshuang,tan xiaosheng,liu yaping,et al.Hypersonins A-D, Polycyclic Polyprenylated Acylphloroglucinols with a 1,2-seco-Homoadamantane Architecture from Hypericum wilsonii[J].JOURNAL OF NATURAL PRODUCTS.2020,83(6):1804-1809.doi:10.1021/acs.jnatprod.9b01187.
APA：
xie,shuangshuang,tan,xiaosheng,liu,yaping,duan,yulin,chen,gang...&zhang,yonghui.(2020).Hypersonins A-D, Polycyclic Polyprenylated Acylphloroglucinols with a 1,2-seco-Homoadamantane Architecture from Hypericum wilsonii.JOURNAL OF NATURAL PRODUCTS,83,(6)
MLA：
xie,shuangshuang,et al."Hypersonins A-D, Polycyclic Polyprenylated Acylphloroglucinols with a 1,2-seco-Homoadamantane Architecture from Hypericum wilsonii".JOURNAL OF NATURAL PRODUCTS 83..6(2020):1804-1809
