Two new adamantyl-like polyprenylated acylphloroglucinols, hyperattenins J (1) and K (2), were isolated from the aerial parts of Hypericum attenuatum choisy. Their structures and absolute configurations were elucidated by rigorous spectroscopic analyses including NMR, HRESIMS, and electronic circular dichroism (ECD). Hyperattenin J (1) features by a unique furan-fused adamantyl core structure with an unusual hemiacetal group. Hyperattenin K (2) exhibited inhibitory effects on HIV-1 replication in C8166 cells and moderate cytotoxicity against the HL-60 and A-549 cell lines. The possible biogenetic pathway of 1 is also discussed. (C) 2015 Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of China [31370372, 31200258, 81202423]; Program for New Century Excellent Talents in University, State Education Ministry of China [NCET-2008-0224]; National Science and Technology Project of China [2011ZX09102-004]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Dongyan,Zhu Hucheng,Qi Changxing,et al.Two new adamantyl-like polyprenylated acylphloroglucinols from Hypericum attenuatum choisy[J].TETRAHEDRON LETTERS.2015,56(15):1953-1955.doi:10.1016/j.tetlet.2015.02.056.
APA：
Li, Dongyan,Zhu, Hucheng,Qi, Changxing,Xue, Yongbo,Yao, Guangmin...&Zhang, Yonghui.(2015).Two new adamantyl-like polyprenylated acylphloroglucinols from Hypericum attenuatum choisy.TETRAHEDRON LETTERS,56,(15)
MLA：
Li, Dongyan,et al."Two new adamantyl-like polyprenylated acylphloroglucinols from Hypericum attenuatum choisy".TETRAHEDRON LETTERS 56..15(2015):1953-1955
