Hypericum japonicum (Guttiferae), a type of annual or perennial herb, has been historically applied to cure infectious hepatitis, acute and chronic hepatitis, gastrointestinal disorder, and internal hemorrhage. In our successive studies on the genus Hypericum, two new alpha-pyrones termed japopyrones A and B (1 and 2) were isolated from H. japonicum. Their structures and absolute configurations were established by the comprehensive analyses of spectroscopic data, the application of the Single-crystal X-ray diffraction structural analysis, and the experimental electronic circular dichroism (ECD) spectra. Bioactivity screenings suggested that compound 2 possessed the potential inhibition efficacy on lytic replication of Kaposi's sarcoma associated herpesvirus (KSHV) with an IC50 29.46 mu M and a selective index of higher than 6.79, respectively.
基金：
Program for New Century Excellent Talents in University; State Education Ministry of China [2008-0224]; National Natural Science Foundation of China [81573316, 31200258, 21502057, 31500281]
第一作者单位：[1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Linzhen,Wang Zhenzhen,Zhang Jinwen,et al.Two New Bioactive α-Pyrones from Hypericum japonicum[J].MOLECULES.2016,21(4):doi:10.3390/molecules21040515.
APA：
Hu, Linzhen,Wang, Zhenzhen,Zhang, Jinwen,Lu, Yuanyuan,Wang, Kaiping...&Zhang, Yonghui.(2016).Two New Bioactive α-Pyrones from Hypericum japonicum.MOLECULES,21,(4)
MLA：
Hu, Linzhen,et al."Two New Bioactive α-Pyrones from Hypericum japonicum".MOLECULES 21..4(2016)
