Zanthoxylum schinifolium Sieb. et Zucc. (Rutaceae), a dioecious shrub with hooked prickly branches, has been used as folk medicine for the treatment of the common cold, stomach ache, diarrhea, and jaundice in China, Korea, and Japan. In our phytochemical investigations on this genus, a new megastigmane sesquiterpenoid, which is referred to as schinifolenol A (1), was isolated from Z. schinifolium. The stereochemistry was characterized via the analyses of extensive spectra. The absolute configuration was established by the application of a modified Mosher's experiment and assisted by a time-dependent density functional theory (TD-DFT) on calculated electronic circular dichroism (ECD). Bioactivity screenings showed that compound 1 exhibited a safe hypotoxicity and a better selectivity on anti-Kaposi's sarcoma associated herpes virus (KSHV).
基金：
Program for New Century Excellent Talents in University; State Education Ministry of China [2008-0224]; National Natural Science Foundation of China [81573316, 31200258, 21502057, 31500281]
第一作者单位：[1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China[2]Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Linzhen,Wang Kongchao,Wang Zhenzhen,et al.A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc[J].MOLECULES.2016,21(3):doi:10.3390/molecules21030383.
APA：
Hu, Linzhen,Wang, Kongchao,Wang, Zhenzhen,Liu, Junjun,Wang, Kaiping...&Zhang, Yonghui.(2016).A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc.MOLECULES,21,(3)
MLA：
Hu, Linzhen,et al."A New Megastigmane Sesquiterpenoid from Zanthoxylum Schinifolium Sieb. et Zucc".MOLECULES 21..3(2016)
