Twelve new megastigmane sesquiterpenoids, wilsonols A L (1-12), were isolated from the leaves of Cinnamomum wilsonii, along with seven known analogues (13-19). The structures of compounds 1-12 were established by spectroscopic analyses. The absolute configurations of 1-5 were determined by single-crystal X-ray diffraction analysis with Cu K alpha irradiation, and the absolute configurations of 6-12 were determined by the modified Mosher's method. Compounds 1-9 and 13-19 were evaluated for in vitro cytotmdcity against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7, and SW-480, and compared against the Beas-2B immortalized (noncancerous) human bronchial epithelial cell line. Compound 13 exhibited IC50 values ranging from 2.5 to 12 mu M and selectivity indices of >10 against SMMC-7721, A-549, and MCF-7 cell lines. Selected compounds were evaluated for in vitro immunomodulatory activity.
基金：
Scientific Research Foundation for the Returned Oversea Chinese Scholars, State Education Ministry of China [2010-1561]; Program for Youth Chutian Scholar of Hubei Province of China [2011-6]; Program for New Century Excellent Talents in University, State Education Ministry of China [NCET-2008-0224]
第一作者单位：[1]Huazhong Univ Sci & Technol, Sch Pharm, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Shu Penghua,Wei Xialan,Xue Yongbo,et al.Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii[J].JOURNAL OF NATURAL PRODUCTS.2013,76(7):1303-1312.doi:10.1021/np4002493.
APA：
Shu, Penghua,Wei, Xialan,Xue, Yongbo,Li, Weijie,Zhang, Jinwen...&Zhang, Yonghui.(2013).Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii.JOURNAL OF NATURAL PRODUCTS,76,(7)
MLA：
Shu, Penghua,et al."Wilsonols A-L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii".JOURNAL OF NATURAL PRODUCTS 76..7(2013):1303-1312
