Twenty-one benzoylated phloroglucinol derivatives bearing homoadamantyl frameworks were isolated from the aerial parts of Hypericum sampsonii, including two new ones named hyperisampsins N and 0 (1 and 2). The structures of 1 and 2 were elucidated by extensive NMR and mass spectrometric analyses. Their absolute configurations were further determined by using TDDFT ECD calculations. Compounds 2, 7, and 8 were evaluated for their cytotoxic activities against five human cancer cell lines, of which, 2 and 8 exhibited significant cytotoxic activities toward HL-60 cell and moderate activities against others cell lines. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
基金：
Program for New Century Excellent Talents in University, State Education Ministry of China [NCET-2008-0224]; National Science and Technology Project of China [2011ZX09102-004]; National Natural Science Foundation of China [31370372, 81573316, 81641129, 21502057]; Fundamental Research Fund for the Central Universities [2016YXMS149]; China Postdoctoral Science Foundation [2015M572154]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhu Hu-Cheng,Chen Chun-Mei,Zhang Jin-Wen,et al.Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives from Hypericum sampsonii[J].CHINESE CHEMICAL LETTERS.2017,28(5):986-990.doi:10.1016/j.cclet.2016.11.014.
APA：
Zhu, Hu-Cheng,Chen, Chun-Mei,Zhang, Jin-Wen,Guo, Yi,Tan, Dong-Dong...&Zhang, Yong-Hui.(2017).Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives from Hypericum sampsonii.CHINESE CHEMICAL LETTERS,28,(5)
MLA：
Zhu, Hu-Cheng,et al."Hyperisampsins N and O, two new benzoylated phloroglucinol derivatives from Hypericum sampsonii".CHINESE CHEMICAL LETTERS 28..5(2017):986-990
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