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Three new amide derivatives from the fungus Alternaria brassicicola

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单位： [1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. [2]Department of Pharmacy, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430022, China. [3]Department of Pharmacy, Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430033, China.

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关键词： Alternaria brassicicola Secondary metabolites Amide derivatives Structural elucidation

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Three new amide derivatives (alteralkaloids A-C, 1-3) and three known alkaloids (4-6) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis. Compounds 1-3 belong to a class of amide derivatives that have not been found in nature before, sharing the same characteristic signals of the butyl moiety and amide group. These isolated compounds mentioned above were tested for the cytotoxic activity.© 2023. Kunming Institute of Botany, CAS.

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出版当年[2022]版：

大类 | 4 区化学

小类 | 4 区药物化学

最新[2025]版：

大类 | 2 区化学

小类 | 2 区药物化学

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出版当年[2021]版：

无

最新[2023]版：

Q1 CHEMISTRY, MEDICINAL

影响因子： 4.8 最新[2023版] 3.9 最新五年平均 0 出版当年[2021版] 0 出版当年五年平均 0 出版前一年[2020版] 4.7 出版后一年[2022版]

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第一作者单位： [1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

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