Alterbrassicicene A (1), a fusicoccane-derived diterpenoid with an unprecedented framework, together with two known biosynthetic intermediates (2 and 3), were characterized from Alternaria brassicicola. The absolute structure of 1 was assigned by extensive spectroscopic analyses and quantum chemical calculations. Compound 1 represents a newly transformed monocyclic carbon skeleton of a highly functionalized diterpenoid bearing unique dihydro-2(3H)-furanone and 2-cyclopenten1-one motifs. Compound 1 was the first fusicoccane-derived diterpenoid functioning as a potent PPAR-gamma agonist (EC50 = 744.1 nM).
基金：
Programs for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]; National Science Fund for Distinguished Young Scholars [81725021]; Innovative Research Groups of the National Natural Science Foundation of China [81721005]; National Natural Science Foundation of China [21702067, 81573316, 31870326, 81703580]; China Postdoctoral Science Foundation [2017M610479, 2018T110777]
第一作者单位：[1]Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Fengli,Sun Weiguang,Guan Jiankun,et al.Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR-γ Agonistic Activity from Alternaria brassicicola[J].ORGANIC LETTERS.2018,20(24):7982-7986.doi:10.1021/acs.orglett.8b03553.
APA：
Li, Fengli,Sun, Weiguang,Guan, Jiankun,Lu, Yuanyuan,Zhang, Sitian...&Zhang, Yonghui.(2018).Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR-γ Agonistic Activity from Alternaria brassicicola.ORGANIC LETTERS,20,(24)
MLA：
Li, Fengli,et al."Alterbrassicicene A, a Highly Transformed Fusicoccane-Derived Diterpenoid with Potent PPAR-γ Agonistic Activity from Alternaria brassicicola".ORGANIC LETTERS 20..24(2018):7982-7986
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