单位：[1]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China,华中科技大学同济医学院附属同济医院外科学系神经外科[2]Burrell College of Osteopathic Medicine, Las Cruces, NM, United States,[3]Department of Operating Room,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院护理部手术室
The extracellular matrix is composed of a variety of macromolecular substances secreted by cells, which form a complex network that supports and connects tissue structures, regulates the morphogenesis of tissues, and maintains the physiological activities of cells. Tenascin-C, a secreted extracellular matrix glycoprotein, is abundantly expressed after exposure to pathological stimuli. It plays an important regulatory role in brain tumors, vascular diseases, and neurodegenerative diseases by mediating inflammatory responses, inducing brain damage, and promoting cell proliferation, migration, and angiogenesis through multiple signaling pathways. Therefore, tenascin-C may become a potential therapeutic target for intracranial diseases. Here, we review and discuss the latest literature regarding tenascin-C, and we comprehensively explain the role and clinical significance of tenascin-C in intracranial diseases.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671154]
第一作者单位：[1]Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan, China,
通讯作者：
推荐引用方式(GB/T 7714)：
Hanmin Chen,Xiangyue Zhou,Lenahan Cameron,et al.Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications[J].FRONTIERS IN NEUROLOGY.2020,11:doi:10.3389/fneur.2020.576230.
APA：
Hanmin, Chen,Xiangyue, Zhou,Lenahan, Cameron,Ling, Wang,Yibo, Ou&Yue, He.(2020).Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications.FRONTIERS IN NEUROLOGY,11,
MLA：
Hanmin, Chen,et al."Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications".FRONTIERS IN NEUROLOGY 11.(2020)
