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Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases

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收录情况： ◇ SCIE

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单位： [1]Brain Science and Advanced Technology Institute, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China. [2]Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China. [3]Hubei Key Laboratory of Nerve Injury and Functional Reconstruction, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

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关键词： Huntingtin-associated protein 1 neurodegenerative diseases intracellular trafficking aging selective neurodegeneration

摘要：

Huntingtin-associated protein 1 (HAP1), the first identified HTT-binding partner, is highly expressed in the central nervous system, and has been found to associated with neurological diseases. Mounting evidence suggests that HAP1 functions as a component of cargo-motor molecules to bind various proteins and participates in intracellular trafficking. It is known that the failure of intracellular transport is a key contributor to the progression of neurodegenerative disorders (NDs) including Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), spinal and bulbar muscular atrophy (SBMA) and spinocerebellar ataxia (SCA). The link between HAP1 and various NDs is supported by growing evidence. This review aims to provide a comprehensive overview of the intracellular trafficking function of HAP1 and its involvement in NDs.Copyright © 2023 Chen, He, Su, Zeng and Xu.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 3 区神经科学 3 区老年医学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区老年医学 3 区神经科学

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出版当年[2021]版：

Q1 NEUROSCIENCES Q2 GERIATRICS & GERONTOLOGY

最新[2023]版：

Q2 GERIATRICS & GERONTOLOGY Q2 NEUROSCIENCES

影响因子： 4.1 最新[2023版] 4.6 最新五年平均 5.702 出版当年[2021版] 6.223 出版当年五年平均 5.75 出版前一年[2020版] 4.8 出版后一年[2022版]

第一作者：

第一作者单位： [1]Brain Science and Advanced Technology Institute, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China. [2]Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China.

通讯作者：

通讯机构： [1]Brain Science and Advanced Technology Institute, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China. [2]Geriatric Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China.

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Huntingtin-associated protein 1-associated intracellular trafficking in neurodegenerative diseases

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