详情页 - 聚合机构库演示平台

当前位置：首页 > 详情页

Recent advances of focused ultrasound induced blood-brain barrier opening for clinical applications of neurodegenerative diseases

文献详情

资源类型：

Pubmed体系：

作者：

单位： [1]Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]School of Pharmacy, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, Hainan Medical University, Haikou 571199, China [3]Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai 200000, China

出处：

DOI：

ISSN：

关键词： Focused ultrasound Microbubbles Blood-brain barrier Cavitation effect Neurodegenerative diseases Clinical applications

摘要：

With the aging population on the rise, neurodegenerative disorders have taken center stage as a significant health concern. The blood-brain barrier (BBB) plays an important role to maintain the stability of central nervous system, yet it poses a formidable obstacle to delivering drugs for neurodegenerative disease therapy. Various methods have been devised to confront this challenge, each carrying its own set of limitations. One particularly promising noninvasive approach involves the utilization of focused ultrasound (FUS) combined with contrast agents-microbubbles (MBs) to achieve transient and reversible BBB opening. This review provides a comprehensive exploration of the fundamental mechanisms behind FUS/MBs-mediated BBB opening and spotlights recent breakthroughs in its application for neurodegenerative diseases. Furthermore, it addresses the current challenges and presents future perspectives in this field.Copyright © 2024. Published by Elsevier B.V.

语种：

PubmedID：

中科院(CAS)分区：

出版当年[2023]版中科院分区表Review为是的期刊

：

大类 | 1 区

医学

小类 | 1 区药学

最新[2025]版

：

大类 | 1 区

医学

小类 | 1 区药学

第一作者：

第一作者单位： [1]Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]School of Pharmacy, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, International Joint Research Center of Human-machine Intelligent Collaborative for Tumor Precision Diagnosis and Treatment of Hainan Province, Hainan Medical University, Haikou 571199, China

共同第一作者：

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]超声联合微泡技术在开放血脑屏障中的研究进展 [2]Phillyrin Prevents Neuroinflammation-Induced Blood-Brain Barrier Damage Following Traumatic Brain Injury via Altering Microglial Polarization [3]Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications [4]Pleiotropic Role of Tenascin-C in Central Nervous System Diseases: From Basic to Clinical Applications [5]Increase in Blood-Brain Barrier (BBB) Permeability Is Regulated by MMP3 via the ERK Signaling Pathway [6]Caspase-1: A Promising Target for Preserving Blood-Brain Barrier Integrity in Acute Stroke [7]Progresses of liver carcinoma targeted therapy mediated by ultrasound and microbubbles [8]Intra-hematoma Rosiglitazone infusion therapy attenuates blood-brain barrier disruption after intracerebral hemorrhage in rabbits [9]MicroRNA-130a regulates cerebral ischemia-induced blood-brain barrier permeability by targeting Homeobox A5 [10]超声联合微泡介导肝癌靶向治疗的研究进展