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Fibrinogen-like protein 2 in inflammatory diseases: A future therapeutic target

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收录情况： ◇ SCIE

作者：

单位： [1]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]Institute of Allergy and Clinical Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [3]Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, China

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关键词： FGL2 Immunomodulatory role Inflammatory diseases Therapeutic target

摘要：

Fibrinogen-like protein 2 (FGL2), a member of the fibrinogen family, exists as a membrane-bound protein with immune-associated coagulation activity and a soluble form possessing immunosuppressive functions. The immunomodulatory role of FGL2 is evident in fibrin deposition-associated inflammatory diseases and cancer, suggesting that FGL2 expression could be exploited as a disease biomarker and a therapeutic target. Recently, in vitro studies and knockout and transgenic animal FGL2 models have been used by us and others to reveal the involvement of FGL2 in the pathogenesis of various inflammatory diseases. This review summarizes our current knowledge of the immunomodulatory role of FGL2 in inflammatory diseases and examines the role of FGL2 as a potential therapeutic target.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

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出版当年[2022]版：

大类 | 2 区医学

小类 | 2 区免疫学 2 区药学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区药学 3 区免疫学

JCR分区：

出版当年[2021]版：

Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY Q2 IMMUNOLOGY

影响因子： 4.8 最新[2023版] 5 最新五年平均 5.714 出版当年[2021版] 5.597 出版当年五年平均 4.932 出版前一年[2020版] 5.6 出版后一年[2022版]

第一作者：

第一作者单位： [1]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]Institute of Allergy and Clinical Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [3]Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, China

通讯作者：

通讯机构： [1]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]Institute of Allergy and Clinical Immunology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [3]Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, China [*1]Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,1095 Jiefang Avenue,Wuhan 430030,China

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Fibrinogen-like protein 2 in inflammatory diseases: A future therapeutic target

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