The Notch pathway is involved in cell proliferation, differentiation and survival. The Notch signaling pathway is one of the most commonly activated signaling pathways in cancer. Alterations include activating mutations and amplification of the Notch pathway, which play key roles in the progression of cancer. Accumulating evidence suggests that the pharmacological inhibition of this pathway can overcome chemoresistance. Efforts have been taken to develop Notch inhibitors as a single agent or in combination. with clinically used chemotherapeutics to treat cancer. Some Notch inhibitors have been demonstrated to have therapeutic efficacy in preclinical studies. This review summarizes the recent studies and clinical evaluations of the Notch inhibitors in cancer. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.orgfficensesiby-nc-nd/4.0/).
基金：
China NSFCNational Natural Science Foundation of China (NSFC) [81172422, 81572608, 81261120395, 81301929, 81372434]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Wuhan 430030, Peoples R China;
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Wuhan 430030, Peoples R China;[4]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, 1095 Jiefang Ave, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Yuan Xun,Wu Hua,Xu Hanxiao,et al.Notch signaling: An emerging therapeutic target for cancer treatment[J].CANCER LETTERS.2015,369(1):20-27.doi:10.1016/j.canlet.2015.07.048.
APA：
Yuan, Xun,Wu, Hua,Xu, Hanxiao,Xiong, Huihua,Chu, Qian...&Wu, Kongming.(2015).Notch signaling: An emerging therapeutic target for cancer treatment.CANCER LETTERS,369,(1)
MLA：
Yuan, Xun,et al."Notch signaling: An emerging therapeutic target for cancer treatment".CANCER LETTERS 369..1(2015):20-27
医学