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Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Bldg 303,1095 Jie Fang Ave, Wuhan 430030, Peoples R China

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关键词： Notch signaling Epithelial-mesenchymal transition (EMT) Cancer stem cells (CSCs) Non-small-cell lung cancer (NSCLC) Gamma secretase inhibitor

摘要：

Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of migration and invasion, stem cell like characteristics and therapeutic resistance. Notch signaling regulates cell-cell connection, cell polarity and motility during organ development. Recent studies demonstrate that Notch signaling plays an important role in lung cancer initiation and cross-talks with several transcriptional factors to enhance EMT, contributing to the progression of non-small cell lung cancer (NSCLC). Correspondingly, blocking of Notch signaling inhibits NSCLC migration and tumor growth by reversing EMT. Clinical trials have showed promising effect in some cancer patients received treatment with Notch1 inhibitor. This review attempts to provide an overview of the Notch signal in NSCLC: its biological significance and therapeutic application.

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出版当年[2013]版：

大类 | 2 区医学

小类 | 3 区血液学 3 区肿瘤学

最新[2025]版：

大类 | 1 区

医学

小类 | 1 区血液学 1 区肿瘤学

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出版当年[2012]版：

Q1 HEMATOLOGY Q1 ONCOLOGY

最新[2023]版：

Q1 HEMATOLOGY Q1 ONCOLOGY

影响因子： 29.9 最新[2023版] 27.1 最新五年平均 4.458 出版当年[2012版] 4.099 出版当年五年平均 3.99 出版前一年[2011版] 4.933 出版后一年[2013版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, Bldg 303,1095 Jie Fang Ave, Wuhan 430030, Peoples R China

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