单位：[1]Anesthesiology Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院麻醉学研究所麻醉科[2]Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院麻醉科[3]School of Psychology, Social Work and Human Sciences, University of West London, Brentford, UK[4]Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China华中科技大学同济医学院附属同济医院肿瘤科[5]MBBS, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Chronic pain is among the most disabling and costly disorders, with prevalence ranging from 10% to 55%. However, current therapeutic strategies for chronic pain are unsatisfactory due to our poor understanding of its mechanisms. Thus, novel therapeutic targets need to be found in order to improve these patients' quality of life. PI3K and its downstream Akt are widely expressed in the spinal cord, particularly in the laminae I-IV of the dorsal horn, where nociceptive C and A delta fibers of primary afferents principally terminate. Recent studies have demonstrated their critical roles in the development and maintenance of chronic pain. In this review, we summarized the roles and mechanisms of PI3K/Akt pathway in the progression of chronic pain through sciatic nerve injury, diabetic neuropathy, spinal cord injury, bone cancer, opioid tolerance, or opioid-induced hyperalgesia.
基金：
National Natural Science Foundation of People's Republic China [81400917, 81371250, 81571053]; National Natural Science Foundation of Hubei Province [2014CFB449]; Specialized Research Fund for the Doctoral Program of Higher EducationSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20130142120102]; HUST [2014QT021]
第一作者单位：[1]Anesthesiology Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China[2]Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Shu-Ping,Zhou Ya-Qun,Liu Dai-Qiang,et al.PI3K/Akt Pathway: A Potential Therapeutic Target for Chronic Pain[J].CURRENT PHARMACEUTICAL DESIGN.2017,23(12):1860-1868.doi:10.2174/1381612823666170210150147.
APA：
Chen, Shu-Ping,Zhou, Ya-Qun,Liu, Dai-Qiang,Zhang, Wen,Manyande, Anne...&Omar, Deeq Mohamed.(2017).PI3K/Akt Pathway: A Potential Therapeutic Target for Chronic Pain.CURRENT PHARMACEUTICAL DESIGN,23,(12)
MLA：
Chen, Shu-Ping,et al."PI3K/Akt Pathway: A Potential Therapeutic Target for Chronic Pain".CURRENT PHARMACEUTICAL DESIGN 23..12(2017):1860-1868
：