Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM)
单位：[1]Huazhong Univ Sci & Technol, Dept Radiol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China放射科华中科技大学同济医学院附属同济医院[2]Weill Cornell Med Coll, Dept Radiol, New York, NY USA[3]Weill Cornell Med Coll, Dept Neurol, New York, NY USA[4]Weill Cornell Med Coll, Dept Healthcare Policy & Res, New York, NY USA[5]Cornell Univ, Dept Biomed Engn, Ithaca, NY USA
PurposeTo measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM). Materials and MethodsThe study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow-up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change. ResultsLesion susceptibility values relative to normal-appearing white matter (NAWM) changed from 3.616.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 +/- 10.23 ppb when not-enhanced-with-Gd at the follow-up MRI (P < 0.001). ConclusionMS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426-432.
基金：
U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Neurological Disorders and Stroke [NS090464]; U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering [EB13443]; National Natural Science Foundation of China [81401390]
第一作者单位：[1]Huazhong Univ Sci & Technol, Dept Radiol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China
通讯作者：
通讯机构：[2]Weill Cornell Med Coll, Dept Radiol, New York, NY USA[5]Cornell Univ, Dept Biomed Engn, Ithaca, NY USA[*1]Weill Cornell Med Coll, 515 E 71th St,S-104, New York, NY 10021 USA
推荐引用方式(GB/T 7714)：
Zhang Yan,Gauthier Susan A.,Gupta Ajay,et al.Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM)[J].JOURNAL OF MAGNETIC RESONANCE IMAGING.2016,44(2):426-432.doi:10.1002/jmri.25144.
APA：
Zhang, Yan,Gauthier, Susan A.,Gupta, Ajay,Comunale, Joseph,Chia-Yi Chiang, Gloria...&Wang, Yi.(2016).Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM).JOURNAL OF MAGNETIC RESONANCE IMAGING,44,(2)
MLA：
Zhang, Yan,et al."Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM)".JOURNAL OF MAGNETIC RESONANCE IMAGING 44..2(2016):426-432
