Adenovirus E1B 55-kilodalton (E1B-55K) mediated DAXX degradation represents a potential mechanism by which E1B-55K sensitizes cancer cells to chemotherapy. Here we report the effects of E1B-55K-mediated DAXX degradation in chemoresistant ovarian cancer cells on response to chemotherapy. Cells with E1B-55K expression were more sensitive to cisplatin than cells without E1B-55K expression. In vivo C13* xenograft studies showed that the combination of cisplatin and E1B-55K was markedly more effective to slow tumor growth and to confer prolonged survival of tumor-bearing mice than either cisplatin or E1B-55K alone. Our studies show that DAXX plays an important role in cisplatin resistance in ovarian cancer, and strategies that promote DAXX degradation such as E1B-55K expression in combination with cisplatin can overcome drug resistance and improve responses to standard chemotherapy. These results also indicate that E1B-55K might be a novel agent for enhancing treatment responses for cisplatin-resistant ovarian cancer.
基金：
National Natural Science Foundation of China [81202059, 81372801, 81572570, 81772787]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Dept Gynecol & Obstet,Wuhan 430030,Hubei,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Qiang,Wang Junnai,Liao Daiqing,et al.Degradation of DAXX by adenovirus type 12 E1B-55K circumvents chemoresistance of ovarian cancer to cisplatin[J].VIROLOGY.2018,521:118-128.doi:10.1016/j.virol.2018.05.026.
APA：
Li, Qiang,Wang, Junnai,Liao, Daiqing,Ai, Jihui,Jin, Lei&Gao, Qinglei.(2018).Degradation of DAXX by adenovirus type 12 E1B-55K circumvents chemoresistance of ovarian cancer to cisplatin.VIROLOGY,521,
MLA：
Li, Qiang,et al."Degradation of DAXX by adenovirus type 12 E1B-55K circumvents chemoresistance of ovarian cancer to cisplatin".VIROLOGY 521.(2018):118-128
