Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is closely related with chemoresistance of solid tumors. The purpose of this study was to investigate the ability of noscapine to inhibit HIF-1 alpha and sensitize ovarian cancer cells to cisplatin (DDP) under hypoxic conditions. Herein, we report that noscapine sensitized cobalt-induced chemoresistant ovarian cancer cells to DDP-induced apoptosis and inhibition of cell proliferation. Noscapine also promoted proteasome-mediated degradation of cobalt-stabilized HIF-1 alpha protein, with subsequent inhibition of HIF-1 transcriptional activity. These data establish noscapine as a small molecule inhibitor of HIF-1 alpha and provide an evidence for its combination with DDP in combating ovarian cancer chemoresistance. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
基金：
Chenguang Project for Youth of Wuhan City [200750731294]; National Science Foundation of China [30770942]
第一作者单位：[2]Huazhong Univ Sci & Technol,Tongji Hosp,Inst Pathol,Wuhan 430030,Hubei,Peoples R China[3]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pathol, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Su Wenjing,Huang Lei,Ao Qilin,et al.Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α[J].CANCER LETTERS.2011,305(1):94-99.doi:10.1016/j.canlet.2011.02.031.
APA：
Su, Wenjing,Huang, Lei,Ao, Qilin,Zhang, Qinghua,Tian, Xun...&Lu, Yunping.(2011).Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α.CANCER LETTERS,305,(1)
MLA：
Su, Wenjing,et al."Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α".CANCER LETTERS 305..1(2011):94-99
医学