Zinc (Zn) is an essential trace element that modulate innate and acquired immune responses, and its deficiency triggers lymphopenia. However, the precise mechanisms underlying zinc-mediated lymphocyte maintenance have not been well clarified. Here, we have successfully generated a zip6 null mutant zebrafish line using TALENs. The Zip6-null mutant zebrafish developed normally during gastrulation. Loss of zip6 in zebrafish resulted in significant T lymphocyte reduction and a decrease in intracellular Zn levels. And the zip6 deficiency increases caspase-related cell apoptosis in both zebrafish cells and human T cells. Our results suggest that ZIP6 plays a critical part in T cell development, and enhance our understanding of Zn homeostasis and immune system maintenance. (C) 2019 Elsevier Inc. All rights reserved.
基金：
National Natural Science Funds (NNSF) of China [81600125, 81230052, 81570197, 81800160]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Hematol,Wuhan 430030,Hubei,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Canc Biol Res Ctr,Wuhan 430030,Hubei,Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Dept Hematol,Wuhan 430030,Hubei,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Canc Biol Res Ctr,Wuhan 430030,Hubei,Peoples R China
推荐引用方式(GB/T 7714)：
Zhao Lei,Tan Jiaqi,Li Dan,et al.SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2019,511(4):896-902.doi:10.1016/j.bbrc.2019.02.148.
APA：
Zhao, Lei,Tan, Jiaqi,Li, Dan,Jiang, Lijun,Li, Tongjuan...&Zhou, Jianfeng.(2019).SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,511,(4)
MLA：
Zhao, Lei,et al."SLC39A6/ZIP6 is essential for zinc homeostasis and T-cell development in zebrafish".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 511..4(2019):896-902
