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The influences of age on T lymphocyte subsets in C57BL/6 mice

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单位： [a]Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China [b]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China [c]School of Public Health, Wuhan University of Science and Technology, Wuhan, 430065, China [d]Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, 200065, China [e]Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, Xincun Road 389, Shanghai, 200065, China [f]Department of Hematology, Tongji Hospital of Tongji University, No. 389 XinCun Road, Shanghai, 200065, China [g]Department of Oncology, Shanghai Medical College, Fudan University, 270 DongAn Road, Shanghai 200032, China

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关键词： Aging C57BL/6 mice Immunosenescence T lymphocyte subsets

摘要：

The aim of this study is to evaluate the age related changes of T lymphocyte subsets in C57BL/6 mice and immune function. Multi-color immunofluorescence techniques that were used to analyse relative numbers of T lymphocyte subsets include CD4+, CD8+, naive and memory CD4+ and CD8+, CD8+CD28+ T cells in peripheral blood of C57BL/6 mice from different age groups (Group I: 2 months old; Group II: 7 months old; Group III: 21 months old); Splenocytes isolated from different group mice were stimulated with Con A to evaluate the proliferative ability. Compared with group I, group II had a significant reduction in the percentage of CD4+, naive CD4+ and CD8+ T cells and an increase in the percentage of CD8+ T cells, while group III had a significant reduction in the percentage of CD4+, naive CD4+ and CD8+ T cells and increase in the percentage of CD8+, memory CD4+ and CD8+ T cells in peripheral blood. Compared with group II, group III had a significant reduction in the percentage of naive CD8+ T cells and increase in the percentage of memory CD4+ and CD8+, CD8+CD28+ T cells in peripheral blood. The T lymphocyte proliferation in vitro showed that groups II and III had a lower proliferative capacity than group I, between groups II and III, there was not a significant difference. We provide relative values for the T lymphocyte subsets in the different age groups of C57BL/6 mice. The immune system began aging at 7 months old in C57BL/6 mice under a specific pathogen free environment. © 2016 The Authors

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出版当年[2016]版：

大类 | 4 区生物

小类 | 4 区生物学

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第一作者：

第一作者单位： [a]Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China [b]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China [g]Department of Oncology, Shanghai Medical College, Fudan University, 270 DongAn Road, Shanghai 200032, China

通讯作者：

通讯机构： [a]Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China [b]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China [c]School of Public Health, Wuhan University of Science and Technology, Wuhan, 430065, China [d]Translational Center for Stem Cell Research, Tongji Hospital, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, 200065, China [g]Department of Oncology, Shanghai Medical College, Fudan University, 270 DongAn Road, Shanghai 200032, China

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