Maternal Preconception Glucose Homeostasis and Insulin Resistance Are Associated with Singleton and Twin Birthweight of Neonates Conceived by PCOS Women Undergoing IVF/ICSI Cycles
单位：[1]Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.[2]National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.[3]Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100191, China.[4]Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China.[5]Reproductive Medicine Center, Tongji Hospital, Tongji Medicine College, Huazhong University of Science and Technology, Wuhan 430074, China.妇产科学系计划生育专科华中科技大学同济医学院附属同济医院[6]Obstetrical Department, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.[7]National Center for Healthcare Quality Management in Obstetrics, Beijing 100191, China.[8]Beijing Advanced Innovation Center for Genomics, Peking University, Beijing 100191, China.[9]Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100191, China.
Polycystic ovary syndrome (PCOS) can induce fertility and metabolism disorders, which may increase the prevalence of glucose metabolism disorders and cause health hazards to women and their offspring. We aim to evaluate the effect of maternal preconception glucose metabolism on neonatal birthweight in PCOS women undergoing IVF/ICSI cycles. We retrospectively analyzed 269 PCOS women who delivered 190 singletons and 79 twins via IVF/ICSI at a reproductive center. The effects of maternal preconception glucose metabolism indicators on singleton and twin birthweight were evaluated using generalized linear models and generalized estimate equations, respectively. The potential nonlinear associations were evaluated using generalized additive models. The analyses were further stratified by maternal preconception BMI and delivery mode to evaluate the possible interaction effects. Among PCOS women, maternal preconception fasting plasma glucose (FPG) and glycohemoglobin (HbA1c) had significant negative associations with singleton birthweight (all p for trends = 0.04). We also found an overweight-specific association between elevated maternal preconception 2 h plasma insulin (2hPI) and twin birthweight (p for interactions = 0.05) and a caesarean-specific association between maternal preconception HbA1c and singleton birthweight (p for interactions = 0.02) in PCOS women. Maternal preconception glucose metabolism may affect neonatal birthweight, suggesting the importance of preconception glucose and insulin management for PCOS women. Further large prospective cohorts and animal studies are needed to confirm these findings and investigate the potential mechanisms.
基金：
This work was supported by the National Natural Science Foundation of China (grant
numbers 81701407, 82171626, 82171632, and 82201839), the National Key Research and Development
Program of China (grant numbers 2021YFC2700605, 2022YFC2702901), and the Beijing Science and
Technology Planning Project (grant number Z191100006619085).
第一作者单位：[1]Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.[2]National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.[3]Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100191, China.[4]Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China.
通讯作者：
通讯机构：[1]Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.[2]National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.[3]Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100191, China.[4]Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China.[8]Beijing Advanced Innovation Center for Genomics, Peking University, Beijing 100191, China.[9]Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100191, China.
推荐引用方式(GB/T 7714)：
Jiang Huahua,Guo Yaxin,Chen Lixue,et al.Maternal Preconception Glucose Homeostasis and Insulin Resistance Are Associated with Singleton and Twin Birthweight of Neonates Conceived by PCOS Women Undergoing IVF/ICSI Cycles[J].JOURNAL OF CLINICAL MEDICINE.2023,12(11):doi:10.3390/jcm12113863.
APA：
Jiang Huahua,Guo Yaxin,Chen Lixue,Shi Huifeng,Huang Ning...&Qiao Jie.(2023).Maternal Preconception Glucose Homeostasis and Insulin Resistance Are Associated with Singleton and Twin Birthweight of Neonates Conceived by PCOS Women Undergoing IVF/ICSI Cycles.JOURNAL OF CLINICAL MEDICINE,12,(11)
MLA：
Jiang Huahua,et al."Maternal Preconception Glucose Homeostasis and Insulin Resistance Are Associated with Singleton and Twin Birthweight of Neonates Conceived by PCOS Women Undergoing IVF/ICSI Cycles".JOURNAL OF CLINICAL MEDICINE 12..11(2023)
医学