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Associations betweenPhthalateMetaboliteConcentrationsinFollicularFluidand Reproductive OutcomesamongWomenUndergoing in Vitro Fertilization/ Intracytoplasmic SpermInjectionTreatment

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收录情况： ◇ SCIE

作者：
Yao, Wen[1] * ; Liu, Chong[2] ; Qin, Dan-Yu[1] ; Yuan, Xiao-Qiong[1] ; Yao, Qing-Yun[1] ; Li, Ni-Jie[1] ; Huang, Yong[1] ; Rao, Wen-Tao[1] ; Li, Yu-Ying[1] ; Deng, Yan-Ling[3,4,5] ; Zeng, Qiang[3,4,5] ; Li, Yu-Feng[1,*1] ;
单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, Wuhan, Hubei, Peoples R China [2]Shanghai Jiao Tong Univ, Sch Publ Hlth, Dept Environm Hlth, Sch Med, Shanghai, Peoples R China [3]Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan, Hubei, Peoples R China [4]Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China [5]Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, State Key Lab Environm Hlth Incubating,Minist Env, Wuhan, Hubei, Peoples R China
出处：
DOI： 10.1289/EHP11998
ISSN：

摘要：
BACKGROUND: Phthalates havebeenreportedtoimpairfertilityinvariousstudies. However, evidenceexploringtheassociationsbetweenphthalate metabolites infollicular fluid (FF) andreproductiveoutcomesislacking. OBJECTIVES: To investigatetheassociationsbetweenphthalatemetaboliteconcentrationsinFFand in vitro fertilization/intracytoplasmic sperminjection (IVF/ICSI) outcomesamongwomenrecruitedfromafertilityclinic. METHODS: We included641womenundergoingIVF/ICSItreatmentfromDecember2018toJanuary2020. Thelevelsofeightphthalatemetabolites, including monoethylphthalate(MEP), mono-isobutylphthalate(MiBP), mono-n-butyl phthalate(MBP), monobenzylphthalate(MBzP), mono(2ethylhexyl) phthalate(MEHP), mono(2-ethyl-5-hydroxyhexyl) phthalate(MEHHP), mono(2-ethyl-5-oxohexyl) phthalate(MEOHP), andmono(2ethyl-5-carboxypentyl) phthalate(MECPP), werequantified inFFcollectedontheoocyteretrievalday. Associationsbetweenquartilesofindividual phthalate metaboliteconcentrationsandnineIVF/ICSIoutcomes, includingoocyteyield, matureoocytenumber, twodistinctpronuclei(2PN) zygote number, fertilizationrate, blastocystformationrate, implantation, clinicalpregnancy, miscarriage, andlivebirth, wereestimatedwithgeneralizedlinear models. Theeffects ofphthalatemixturesonIVF/ICSIoutcomeswereassessedusingBayesiankernelmachineregression(BKMR) models. RESULTS: After adjustingforrelevantconfounders, elevatedquartilesofMBzP, MEHHP, andMEHPinFFwereinverselyassociatedwiththenumbers ofretrievedoocytes, matureoocytes, and2PNzygotes(all p for trends<0:10). Incomparisonwiththelowestquartile, thehighestquartileof molar sumofdi(2-ethylhexyl) phthalatemetabolites(RDEHP) wasassociatedwithareductionof9.1%[95% confidence interval(CI): -17:1%, -0:37%] and10.3%(95% CI: -18:8%, -0:94%) inyieldedoocyteandmatureoocytenumbers, respectively. Furthermore, theBKMRmodelsrevealed inverse associationsbetweenphthalatemixturesandthenumbersofretrievedoocytesandmatureoocytes. Wegenerallyfoundnullresultsforimplantation, clinicalpregnancy, miscarriage, andlivebirth. DISCUSSION: Certain phthalatemetabolitesinFFareinverselyassociatedwiththenumbersofretrievedoocytes, matureoocytes, and2PNzygotes among womenundergoingIVF/ICSItreatment. https://doi.org/10.1289/EHP11998

基金：
National Natural Science Foundation of China [81771654]
语种：
外文
WOS：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学 1 区 毒理学 1 区 公共卫生、环境卫生与职业卫生
最新[2025]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学 1 区 公共卫生、环境卫生与职业卫生 1 区 毒理学
JCR分区：
出版当年[2021]版：
Q1 ENVIRONMENTAL SCIENCES Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Q1 TOXICOLOGY
最新[2023]版：
Q1 ENVIRONMENTAL SCIENCES Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Q1 TOXICOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, Wuhan, Hubei, Peoples R China
通讯作者：
通讯机构： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, Wuhan, Hubei, Peoples R China [*1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Reprod Med Ctr, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China
推荐引用方式(GB/T 7714)：
Yao Wen,Liu Chong,Qin Dan-Yu,et al.Associations betweenPhthalateMetaboliteConcentrationsinFollicularFluidand Reproductive OutcomesamongWomenUndergoing in Vitro Fertilization/ Intracytoplasmic SpermInjectionTreatment[J].ENVIRONMENTAL HEALTH PERSPECTIVES.2023,131(12):doi:10.1289/EHP11998.
APA：
Yao, Wen,Liu, Chong,Qin, Dan-Yu,Yuan, Xiao-Qiong,Yao, Qing-Yun...&Li, Yu-Feng.(2023).Associations betweenPhthalateMetaboliteConcentrationsinFollicularFluidand Reproductive OutcomesamongWomenUndergoing in Vitro Fertilization/ Intracytoplasmic SpermInjectionTreatment.ENVIRONMENTAL HEALTH PERSPECTIVES,131,(12)
MLA：
Yao, Wen,et al."Associations betweenPhthalateMetaboliteConcentrationsinFollicularFluidand Reproductive OutcomesamongWomenUndergoing in Vitro Fertilization/ Intracytoplasmic SpermInjectionTreatment".ENVIRONMENTAL HEALTH PERSPECTIVES 131..12(2023)

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