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KLF4 upregulation is involved in alternative macrophage activation during secondary Echinococcus granulosus infection

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收录情况： ◇ SCIE

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单位： [1]Shihezi Univ, Sch Med, Dept Immunol, Shihezi, Xinjiang, Peoples R China [2]Peoples Liberat Army Gen Hosp, Beijing, Peoples R China [3]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Gen Surg, Shihezi, Xinjiang, Peoples R China [4]Shihezi Univ, Lab Transit Med, Sch Med, Shihezi, Xinjiang, Peoples R China

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关键词： POLARIZATION IMMUNOLOGY EXPRESSION PATHWAY ROLES MODEL MICE

摘要：

The objective of this study was to investigate macrophage polarization during the early stages of secondary Echinococcus granulosus sensu lato (E. granulosus s.l.) infection. We observed an early initial increase in inflammatory genes (peaking at 5-10 days) and a later rise in M (IL-4)-like genes (still rising by day 15). In addition, we showed that the induction of M (IL-4)-like genes was paralleled by an increase in expression of the transcription factor KLF4. Most of the changes observed in vivo were reproduced in vitro upon the culture of normal peritoneal macrophages with live E. granulosus s.l. protoscoleces (PSC), and that knockdown of KLF4 in this system attenuates M (IL-4) differentiation. Our results suggest that KLF4 pathway contributes to the differentiation of macrophages towards M (IL-4)-like phenotype during early stages of secondary E. granulosus s.l. infection.

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出版当年[2018]版：

大类 | 3 区医学

小类 | 3 区寄生虫学 4 区免疫学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区免疫学 4 区寄生虫学

JCR分区：

出版当年[2017]版：

Q2 PARASITOLOGY Q3 IMMUNOLOGY

最新[2023]版：

Q3 PARASITOLOGY Q4 IMMUNOLOGY

影响因子： 1.4 最新[2023版] 1.7 最新五年平均 2.836 出版当年[2017版] 2.364 出版当年五年平均 2.493 出版前一年[2016版] 2.755 出版后一年[2018版]

第一作者：

第一作者单位： [1]Shihezi Univ, Sch Med, Dept Immunol, Shihezi, Xinjiang, Peoples R China

通讯作者：

通讯机构： [1]Shihezi Univ, Sch Med, Dept Immunol, Shihezi, Xinjiang, Peoples R China [*1]Shihezi Univ, Sch Med, Dept Immunol, Shihezi, Xinjiang, Peoples R China [*2]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Gen Surg, Shihezi, Xinjiang, Peoples R China [3]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Gen Surg, Shihezi, Xinjiang, Peoples R China

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