Macrophages in adipose tissue are associated with obesity-induced low-grade inflammation, which contributed to insulin resistance and the related metabolic diseases. Macrophages display phenotypic plasticity, and polarize under the condition of obesity. Epoxyeicosatrienoic Acids (EETs) are lipid mediators that are involved in the regulation of inflammatory cascades and glucose homeostasis. In this mini-review, we briefly summarize the macrophages recruitment, infiltration and polarization in obese mice, and also discuss the immune-metabolic regulatory role of EETs in this process (See Fig. 1).
基金：
Natural Science Foundation of China (NSFC) [81471021]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Div Cardiol,Dept Internal Med,Wuhan 430030,Hubei,Peoples R China[2]Hubei Key Lab Genet & Mol Mech Cardiol Disorders, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Dai Meiyan,Wu Lujin,Tu Ling,et al.The immune-metabolic regulatory roles of epoxyeicosatrienoic acids on macrophages phenotypic plasticity in obesity-related insulin resistance.[J].Prostaglandins Other Lipid Mediat.2018,139:36-40.doi:10.1016/j.prostaglandins.2018.10.003.
APA：
Dai, Meiyan,Wu, Lujin,Tu, Ling,Xu, Xizhen&Wang, Dao Wen.(2018).The immune-metabolic regulatory roles of epoxyeicosatrienoic acids on macrophages phenotypic plasticity in obesity-related insulin resistance..Prostaglandins Other Lipid Mediat,139,
MLA：
Dai, Meiyan,et al."The immune-metabolic regulatory roles of epoxyeicosatrienoic acids on macrophages phenotypic plasticity in obesity-related insulin resistance.".Prostaglandins Other Lipid Mediat 139.(2018):36-40
