The role of PM2.5 in the bronchial asthma remains unclear. In this study, the deficient mice of TLR4-/-, TLR2-/- and MyD88 -/- were used to establish asthma model. The effects of PM2.5 on the inflammatory response in lung tissue of these mice were observed. PM2.5 increased alveolar macrophages and neutrophils, up-regulated the IL-12 and KC expression in WT mice, but down-regulated their levels in TLR2 -/-, TLR4 -/- and MyD88 -/- mice. OVA+PM2.5 stimulated neutrophil count in WT mice, but it decreased in TLR2 -/- and TLR4 -/- mice. OVA+PM2.5 also increased the Eotaxin, IL-5, IL-13 and MCP-3 expression levels, and OVA specific IgE and IgG1 in serum also increased in WT group. PM2.5 may activate NF-kappa B through the TLR2/TLR4/MyD88 signaling pathway and aggravate allergic inflammation of lung in asthmatic mice. The microelements in PM2.5 granules, such as lipopolysaccharide, may be an important factor in the high incidence of asthma.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类|4 区医学
小类|4 区公共卫生、环境卫生与职业卫生4 区环境科学
最新[2025]版：
大类|4 区医学
小类|4 区环境科学4 区公共卫生、环境卫生与职业卫生
JCR分区：
出版当年[2021]版：
Q2ENVIRONMENTAL SCIENCESQ2PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
第一作者单位：[1]Shanxi Acad Med Sci, Shanxi Bethune Hosp, Dept Resp Med, Taiyuan, Shanxi, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Lei,Cui Yanzhi,Liu Hu,et al.PM2.5 aggravates airway inflammation in asthmatic mice: activating NF-κB via MyD88 signaling pathway[J].INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH.2023,33(6):563-574.doi:10.1080/09603123.2022.2041561.
APA：
Wang, Lei,Cui, Yanzhi,Liu, Hu,Wu, Jing,Li, Jie&Liu, Xiansheng.(2023).PM2.5 aggravates airway inflammation in asthmatic mice: activating NF-κB via MyD88 signaling pathway.INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH,33,(6)
MLA：
Wang, Lei,et al."PM2.5 aggravates airway inflammation in asthmatic mice: activating NF-κB via MyD88 signaling pathway".INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH 33..6(2023):563-574
