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Interleukin-25 Enhances Allergic Inflammation through p38MAPK and NF-kappa B Pathways in Mouse Models of Allergic Rhinitis

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Otorhinolaryngol Head & Neck Surg, Wuhan 430030, Peoples R China

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关键词： Allergic rhinitis Interleukin-25 Mice NF-kappa B p38 Mitogen-Activated Protein kinases

摘要：

Interleukin (IL)-25, a cytokine of IL-17 family, can activate p38 Mitogen-Activated Protein kinases(MAPK) and Nuclear Factor(NF)- B pathways to propagate Th2 responses. The allergic rhinitis mouse model was established by stimulating BALB/c mouse with ovalbumin (OVA). Then we detected expression of IL-25 and downstream p38MAPK and NF-kappa B. The expression of IL-25, p38MAPK and NF-kappa B were detected in the OVA-induced allergic rhinitis mouse model. The allergic parameters, such as allergic symptoms, serum OVA-specific immunoglobulin E (IgE) levels and eosinophil infiltration in the nasal mucosa were compared between OVA group and control group. OVA-induced mice displayed significantly higher allergic responses compared with the saline control group. OVA induced mice demonstrated more allergic symptoms, higher serum OVA-specific IgE levels and eosinophil infiltrations. The increased expression of IL-25, p38MAPK and NF-kappa B immunoreactivity were detected in epidermal cells in the OVA group. The mRNA measurement of IL-25, p38MAPK and NF-kappa B showed the same result. IL-25 enhances the OVA-induced allergic rhinitis by activating p38MAPK and NF-kappa B pathways.

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出版当年[2013]版：

大类 | 4 区医学

小类 | 4 区过敏 4 区免疫学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区过敏 4 区免疫学

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出版当年[2012]版：

Q4 IMMUNOLOGY Q4 ALLERGY

最新[2023]版：

Q4 ALLERGY Q4 IMMUNOLOGY

影响因子： 1.2 最新[2023版] 1.3 最新五年平均 0.653 出版当年[2012版] 0.921 出版当年五年平均 0.508 出版前一年[2011版] 1.013 出版后一年[2013版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Otorhinolaryngol Head & Neck Surg, Wuhan 430030, Peoples R China

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