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NKILA inhibits NF-kappa B signaling and suppresses tumor metastasis

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收录情况： ◇ SCIE

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单位： [1]Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China [2]Department of General Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China [3]Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China

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关键词： long non-coding RNA NKILA metastasis esophageal squamous cell carcinoma NF-kappa B

摘要：

The long non-coding RNA (lncRNA) NKILA (nuclear transcription factor NF-kappa B interacting lncRNA) functions as a suppressor in human breast cancer and tongue cancer. However, the clinical significance and biological roles of NKILA in esophageal squamous cell carcinoma (ESCC) remain unknown. In this study, we showed that NKILA was downregulated in ESCC tissues and cancer cells compared with their normal counterparts. Low NKILA expression correlated with large tumor size and advanced TNM stage, and predicted poor overall and disease-free survival of ESCC patients. Further loss-and gain-of-function assays indicated that NKILA inhibited proliferation and migration of ESCC cells in vitro, suppressed tumor growth and lung metastasis in vivo. Mechanistically, NKILA could inhibit phosphorylation of I kappa B alpha, suppress p65 nuclear translocation and downregulate the expression of NF-kappa B target genes in ESCC cells. These results suggest NKILA could suppress malignant development of ESCC via abrogation of the NF-kappa B signaling and may potentially serve as a prognostic marker for ESCC.

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基金编号： 2011CDD193

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出版当年[2017]版：

大类 | 2 区生物

小类 | 3 区细胞生物学

最新[2025]版：

无

JCR分区：

出版当年[2016]版：

Q2 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 4.867 出版当年[2016版] 5.24 出版当年五年平均 3.979 出版前一年[2015版] 5.179 出版后一年[2017版]

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第一作者单位： [1]Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China

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