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Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment

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收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ SSCI ◇ 卓越：重点期刊

作者：

单位： [1]Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Department of Radiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [3]Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China [4]School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing 100876, China [5]University of the Chinese Academy of Sciences, Beijing 100049, China

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关键词： White matter hyperintensities Cognitive impairment Cortical thickness Grey matter volume Replication

摘要：

Grey matter (GM) alterations may contribute to cognitive decline in individuals with white matter hyperintensities (WMH) but no consensus has yet emerged. Here, we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitive impairment (WMH-MCI), 43 WMH patients without cognitive impairment, and 55 healthy controls. Both WMH groups showed GM atrophy in the bilateral thalamus, fronto-insular cortices, and several parietal-temporal regions, and the WMH-MCI group showed more extensive and severe GM atrophy. The GM atrophy in the thalamus and fronto-insular cortices was associated with cognitive decline in the WMH-MCI patients and may mediate the relationship between WMH and cognition in WMH patients. Furthermore, the main results were well replicated in an independent dataset from the Alzheimer's Disease Neuroimaging Initiative database and in other control analyses. These comprehensive results provide robust evidence of specific GM alterations underlying WMH and subsequent cognitive impairment.

基金：

基金编号： 81801146 81871438 81771341 2017CFB392 JQ200036 2019CR106 U01 AG024904 W81XWH-12-2-0012

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出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区神经科学

最新[2025]版：

大类 | 2 区医学

小类 | 2 区神经科学

JCR分区：

出版当年[2019]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q1 NEUROSCIENCES

影响因子： 5.9 最新[2023版] 5.4 最新五年平均 4.326 出版当年[2019版] 3.808 出版当年五年平均 4.246 出版前一年[2018版] 5.203 出版后一年[2020版]

第一作者：

第一作者单位： [1]Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

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通讯作者：

通讯机构： [3]Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China [4]School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing 100876, China [5]University of the Chinese Academy of Sciences, Beijing 100049, China

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