单位：[1]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China神经内科神经科华中科技大学同济医学院附属同济医院[2]Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan, Hubei, China
Background: Cerebral small vessel disease (CSVD) is closely related to gait disorders. Previous studies have found a negative correlation between the severity of MRI white matter hyperintensities (WMH) and gait speed. However, not every individual with WMH experiences a gait disorder.Purpose: To investigate the mechanisms underlying the mismatch between the severity of MRI WMH and gait impairment, in particular in subjects with severe WMH (Fazekas 3, scale 0-3) resulting from vascular disease.Study Type: Cohort.Population: 54 subjects with severe WMH and gait disorder (WMH-GD; 29 males) and 114 subjects with severe WMH with no gait disorder (WMH-nGD; 60 males).Field Strength/Sequence: 3T/diffusion tensor imaging (DTI), and T1-weighted, T2-weighted, FLAIR, DWI, SWI.Assessment: Trace-based spatial statistics analysis (TBSS) approach (fractional anisotropy, FA; mean diffusivity; radial diffusivity; axial diffusivity); Cognitive assessment; Conventional MRI markers of CSVD (WMH, enlarged perivascular spaces, lacunae, and cerebral microbleeds); Gait parameters (gait speed; cadence; stride length; gait cycle duration; step duration; time-up-and-go test, TUG). Gait disorder was defined as a TUG time exceeding 12 sec.Statistical Tests: The t-tests, Mann-Whitney U tests, Chi-square tests, and partial correlation analysis (Pearson or Spearman) were used. P < 0.05 with threshold-free cluster enhancement corrected was considered statistically significant for TBSS.Results: After adjusting for age, sex, height, and other conventional MRI markers of CSVD, the WMH-nGD group showed significantly decreased FA values in the corpus callosum, bilateral superior longitudinal fasciculus, left corona radiata, and left posterior thalamic radiation. There was a significant association between FA values and TUG time, gait speed, and stride length in multiple WM tracts, independent of other conventional CSVD markers.Data Conclusion: This study provides evidence for microstructural damage of specific fibers in WMH-GD subjects compared to WMH-nGD subjects. This may explain the mismatch between WMH and gait impairment in subjects with severe WMH.
基金：
This study was supported by the National Nature Science Foundation of China (82171385 to X. Luo), the Key Research and Development Program of Hubei Province (2020BCA070 to X. Luo), the Application Foundation Frontier Special Project of Wuhan Science and Te [82171385]; National Nature Science Foundation of China [2020BCA070]; Key Research and Development Program of Hubei Province [2020020601012226]; Application Foundation Frontier Special Project of Wuhan Science and Technology Bureau [2019CR106]; Flagship Program of Tongji Hospital [2022CFD063]; Joint Fund for Innovation and Development of Natural Science Foundation of Hubei Province
第一作者单位：[1]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
通讯作者：
通讯机构：[1]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China[2]Hubei Key Laboratory of Neural Injury and Functional Reconstruction, Huazhong University of Science and Technology, Wuhan, Hubei, China[*1]1095 Jiefang Avenue, Wuhan, Hubei, China
推荐引用方式(GB/T 7714)：
Wu Lingshan,Wang Ziyue,Zhou Xirui,et al.Mismatch of MRI White Matter Hyperintensities and Gait Function in Patients With Cerebral Small Vessel Disease[J].JOURNAL OF MAGNETIC RESONANCE IMAGING.2023,doi:10.1002/jmri.29121.
APA：
Wu, Lingshan,Wang, Ziyue,Zhou, Xirui,Kong, Qianqian,Zhang, Yi...&Luo, Xiang.(2023).Mismatch of MRI White Matter Hyperintensities and Gait Function in Patients With Cerebral Small Vessel Disease.JOURNAL OF MAGNETIC RESONANCE IMAGING,,
MLA：
Wu, Lingshan,et al."Mismatch of MRI White Matter Hyperintensities and Gait Function in Patients With Cerebral Small Vessel Disease".JOURNAL OF MAGNETIC RESONANCE IMAGING .(2023)
