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The role of pyroptosis in cognitive impairment

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收录情况： ◇ SCIE

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单位： [1]Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. [2]Department of Thoracic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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关键词： pyroptosis cognitive impaiment NLRP3 inflammasome treatment GSDMD

摘要：

Cognitive impairment is a major global disease, manifests as a decline in cognitive functioning and endangers the health of the population worldwide. The incidence of cognitive impairment has increased rapidly with an increasingly aging population. Although the mechanisms of cognitive impairment have partly been elucidated with the development of molecular biological technology, treatment methods are very limited. As a unique form of programmed cell death, pyroptosis is highly pro-inflammatory and is closely associated with the incidence and progression of cognitive impairment. In this review, we discuss the molecular mechanisms of pyroptosis briefly and the research progress on the relationship between pyroptosis and cognitive impairment and its potential therapeutic values, to provide a reference for research in the field of cognitive impairment.Copyright © 2023 Yang and Tang.

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出版当年[2022]版：

大类 | 2 区

医学

小类 | 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区神经科学

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出版当年[2021]版：

Q2 NEUROSCIENCES

最新[2023]版：

Q2 NEUROSCIENCES

影响因子： 3.2 最新[2023版] 4.3 最新五年平均 5.152 出版当年[2021版] 5.582 出版当年五年平均 4.677 出版前一年[2020版] 4.3 出版后一年[2022版]

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第一作者单位： [1]Department of Oncology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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