RETRACTED: A Cu(II)-based coordination polymer: crystal structure and treatment activity on connective tissue disease via reducing miRNA9 expression (Retracted article. See DEC, 2022)
A new Cu(II)-containing coordination polymer formulated as [Cu(H2L2)(H2O)] (n) (1) has been synthesized by the reaction of Cu(NO3)(2)center dot 3H(2)O with a flexible 1,1 '-(propane-1,3-diyl)bis(1H-imidazole-4,5-dicarboxylic acid (H4L) ligand under hydrothermal conditions. To improve the success rate of the treatment on connective tissue disease, the biological function of 1 was evaluated. First, the expression level of miRNA9 was evaluated with RT-PCR in the connective tissue disease model and normal groups. The influence of the compound on the miRNA9 expression was next explored. The differentiation ability of the tendon stem cell was further measured by evaluating the expression of the PDGF signaling pathway with western blot. Finally, the direct regulation activity of the miRNA9 on PDGF signaling pathway was confirmed with bioinformatic analysis and luciferase reporter assay. Molecular docking was performed to predict the potential binding modes of the complex to PDGF protein, indicating a possible regulation mechanism through DNA interference.
第一作者单位：[1]Naval Mil Med Univ, Joint & Osteopathy Surg Dept, Affiliated Hosp 1, Shanghai Changhai Hosp, Shanghai, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Xue Chenchen,Ju Zeya,Zhang Yongjin,et al.RETRACTED: A Cu(II)-based coordination polymer: crystal structure and treatment activity on connective tissue disease via reducing miRNA9 expression (Retracted article. See DEC, 2022)[J].JOURNAL OF COORDINATION CHEMISTRY.2021,74(7):1066-1078.doi:10.1080/00958972.2021.1887484.
APA：
Xue, Chenchen,Ju, Zeya,Zhang, Yongjin,Zhou, Zhiyou,Liu, Yang...&Bai, Xiangjun.(2021).RETRACTED: A Cu(II)-based coordination polymer: crystal structure and treatment activity on connective tissue disease via reducing miRNA9 expression (Retracted article. See DEC, 2022).JOURNAL OF COORDINATION CHEMISTRY,74,(7)
MLA：
Xue, Chenchen,et al."RETRACTED: A Cu(II)-based coordination polymer: crystal structure and treatment activity on connective tissue disease via reducing miRNA9 expression (Retracted article. See DEC, 2022)".JOURNAL OF COORDINATION CHEMISTRY 74..7(2021):1066-1078
