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A Novel Zn(II) Coordination Polymer: Fluorescence Performances, Molecular Docking and Loaded with Bleomycin-Hydrogels on Hemangiomas

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收录情况： ◇ SCIE

作者：

单位： [1]Department of Vascular Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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关键词： Coordination polymer Fluorescence Hydrogels Bleomycin Hemangiomas

摘要：

In this study, we successfully synthesized an innovative 1D-Zn(II) coordination polymer, denoted as [Zn(L)(H2O)2]n, employing the Schiff base {4-[(2-hydroxy-3-methoxy-benzylidene)-amino]-benzoic acid} (H2L). The Schiff base was obtained through the reaction of 4-aminobenzoic acid and o-vanillin under slow volatilization conditions. The resulting compound exhibits remarkable green fluorescence emission properties, indicating its potential as a novel fluorescent and sensing material. Hydrogels based on hyaluronic acid (HA) and carboxymethyl chitosan (CMCS), denoted as HA/CMCS hydrogels, were synthesized using a chemical method. Additionally, we utilized bleomycin as a model drug to synthesize a novel bleomycin metal gel and assessed its anti-hemangioma activity. Molecular docking simulations revealed that the Zn complex can form stable bonds with the key target, involving the methoxy and carboxyl groups on the Zn complex.© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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出版当年[2023]版：

大类 | 4 区化学

小类 | 4 区生化研究方法 4 区分析化学 4 区物理化学

最新[2025]版：

大类 | 3 区化学

小类 | 4 区生化研究方法 4 区分析化学 4 区物理化学

JCR分区：

出版当年[2022]版：

Q3 BIOCHEMICAL RESEARCH METHODS Q3 CHEMISTRY, ANALYTICAL Q3 CHEMISTRY, PHYSICAL

最新[2023]版：

Q2 BIOCHEMICAL RESEARCH METHODS Q2 CHEMISTRY, ANALYTICAL Q3 CHEMISTRY, PHYSICAL

影响因子： 2.6 最新[2023版] 2.6 最新五年平均 2.7 出版当年[2022版] 2.4 出版当年五年平均 2.525 出版前一年[2021版] 2.6 出版后一年[2023版]

第一作者：

第一作者单位： [1]Department of Vascular Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

通讯作者：

通讯机构： [1]Department of Vascular Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, China [2]Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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A Novel Zn(II) Coordination Polymer: Fluorescence Performances, Molecular Docking and Loaded with Bleomycin-Hydrogels on Hemangiomas

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