During the past decades, tryptophan metabolism disorder was discovered to play a vital and complex role in the development of cancer. Indoleamine 2,3-dioxygenase 2 (IDO2) is one of the initial and rate-limiting enzymes of the kynurenine pathway of tryptophan catabolism. Increasing evidence indicates that IDO2 is upregulated in some tumors and plays a role in the development of cancer. In spite of the growing body of research, few reviews focused on the role of IDO2 in cancer. Here, we review the emerging knowledge on the roles of IDO2 in cancer and its potential as a therapeutic target. Firstly, the main biological features and regulatory mechanisms are reviewed, after which we focus on the expression and roles of IDO2 in cancer. Finally, we discuss the potential of IDO2 as a therapeutic target for cancer treatment.
基金：
State Key Project on Infectious Diseases of China [2018ZX10723204003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81874065, 81500565]; Hepato- Biliary-Pancreatic Malignant Tumor Investigation Fund of Chen Xiaoping Foundation for the Development of Science and Technology of Hubei Province [CXPJJH11800001-2018356]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Hepat Surg Ctr, Wuhan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
li pengcheng,xu weiqi,liu furong,et al.The emerging roles of IDO2 in cancer and its potential as a therapeutic target[J].BIOMEDICINE & PHARMACOTHERAPY.2021,137:doi:10.1016/j.biopha.2021.111295.
APA：
li,pengcheng,xu,weiqi,liu,furong,zhu,he,zhang,lu...&song,jia.(2021).The emerging roles of IDO2 in cancer and its potential as a therapeutic target.BIOMEDICINE & PHARMACOTHERAPY,137,
MLA：
li,pengcheng,et al."The emerging roles of IDO2 in cancer and its potential as a therapeutic target".BIOMEDICINE & PHARMACOTHERAPY 137.(2021)
