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Obtaining PET/CT images from non-attenuation corrected PET images in a single PET system using Wasserstein generative adversarial networks

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单位: [1]Chinese Acad Sci, Lauterbur Res Ctr Biomed Imaging, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China [2]Wuhan Univ Technol, Hubei Key Lab Broadband Wireless Commun & Sensor, Wuhan 430070, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Nucl Med & PET, Wuhan 430000, Peoples R China
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关键词: positron emission tomography (PET) computed tomography (CT) non-attenuation corrected PET (NAC PET) synthesis PET CT image Wasserstein generative adversarial networks (WGAN)

摘要:
Positron emission tomography (PET) imaging plays an indispensable role in early disease detection and postoperative patient staging diagnosis. However, PET imaging requires not only additional computed tomography (CT) imaging to provide detailed anatomical information but also attenuation correction (AC) maps calculated from CT images for precise PET quantification, which inevitably demands that patients undergo additional doses of ionizing radiation. To reduce the radiation dose and simultaneously obtain high-quality PET/CT images, in this work, we present an alternative based on deep learning that can estimate synthetic attenuation corrected PET (sAC PET) and synthetic CT (sCT) images from non-attenuation corrected PET (NAC PET) scans for whole-body PET/CT imaging. Our model consists of two stages: the first stage removes noise and artefacts in the NAC PET images to generate sAC PET images, and the second stage synthesizes CT images from the sAC PET images obtained in the first stage. Both stages employ the same deep Wasserstein generative adversarial network and identical loss functions, which encourage the proposed model to generate more realistic and satisfying output images. To evaluate the performance of the proposed algorithm, we conducted a comprehensive study on a total of 45 sets of paired PET/CT images of clinical patients. The final experimental results demonstrated that both the generated sAC PET and sCT images showed great similarity to true AC PET and true CT images based on both qualitative and quantitative analyses. These results also indicate that in the future, our proposed algorithm has tremendous potential for reducing the need for additional anatomic imaging in hybrid PET/CT systems or the need for lengthy MR sequence acquisition in hybrid PET/MRI systems.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 3 区 工程:生物医学 3 区 核医学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 工程:生物医学 3 区 核医学
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出版当年[2018]版:
Q2 ENGINEERING, BIOMEDICAL Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 ENGINEERING, BIOMEDICAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

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第一作者单位: [1]Chinese Acad Sci, Lauterbur Res Ctr Biomed Imaging, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
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