单位：[1]The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China[2]University of Chinese Academy of Sciences, Beijing, 100049, China[3]Changjiang River Scientific Research Institute, Wuhan, 430010, China[4]Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China华中科技大学同济医学院附属同济医院肝脏外科外科学系
Lead (Pb) is a toxic heavy metal that can cause significant damage to the aquatic ecosystem. In this study, acute toxicity test of lead in rare minnow (Gobiocypris rarus) was conducted. The average LC50 for 96 h of Pb2+ is 423.01 mu g/L (95 % CI: 338.41-531.92 mu g/L). The order of bioaccumulation of Pb2+ was gills>kidney>intestine>liver>muscle>brain. A number of cellular and tissue alterations were observed in the gill, liver, kidney and intestine tissues of Pb2+-treated rare minnows through the histological examination performed by H&E and TEM analyses. Furthermore, we investigated the Pb2+-induced toxicity mechanisms in rare minnow based on transcriptome analyses, and a panel of immune-related genes were identified and evaluated by real-time quantitative PCR. In summary, our work indicates that rare minnow could be a valuable model for studying the mechanisms of lead acute toxicity in fish.
第一作者单位：[1]The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China[2]University of Chinese Academy of Sciences, Beijing, 100049, China
通讯作者：
推荐引用方式(GB/T 7714)：
Shi Lixia,Wang Nenghan,Hu Xudong,et al.Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis[J].ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY.2020,78:doi:10.1016/j.etap.2020.103385.
APA：
Shi, Lixia,Wang, Nenghan,Hu, Xudong,Yin, Dacong,Wu, Chenxi...&Cao, Hong.(2020).Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,78,
MLA：
Shi, Lixia,et al."Acute toxic effects of lead (Pb2+) exposure to rare minnow (Gobiocypris rarus) revealed by histopathological examination and transcriptome analysis".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 78.(2020)
