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Mitochondria-endoplasmic reticulum contacts in sepsis-induced myocardial dysfunction

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收录情况： ◇ SCIE ◇ 预警期刊

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单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Geriatr, Wuhan, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Internal Med,Div Cardiol, Wuhan, Peoples R China

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关键词： sepsis-induced myocardial dysfunction calcium signaling autophagy mitochondrial dynamics ER stress mitochondria-ER contacts inflammation

摘要：

Mitochondrial and endoplasmic reticulum (ER) are important intracellular organelles. The sites that mitochondrial and ER are closely related in structure and function are called Mitochondria-ER contacts (MERCs). MERCs are involved in a variety of biological processes, including calcium signaling, lipid synthesis and transport, autophagy, mitochondrial dynamics, ER stress, and inflammation. Sepsis-induced myocardial dysfunction (SIMD) is a vital organ damage caused by sepsis, which is closely associated with mitochondrial and ER dysfunction. Growing evidence strongly supports the role of MERCs in the pathogenesis of SIMD. In this review, we summarize the biological functions of MERCs and the roles of MERCs proteins in SIMD.

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出版当年[2021]版：

大类 | 3 区生物学

小类 | 2 区发育生物学 3 区细胞生物学

最新[2025]版：

大类 | 2 区生物学

小类 | 2 区发育生物学 3 区细胞生物学

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出版当年[2020]版：

Q1 DEVELOPMENTAL BIOLOGY Q2 CELL BIOLOGY

最新[2023]版：

Q1 DEVELOPMENTAL BIOLOGY Q2 CELL BIOLOGY

影响因子： 4.6 最新[2023版] 5.2 最新五年平均 6.684 出版当年[2020版] 7.219 出版当年五年平均 5.186 出版前一年[2019版] 6.081 出版后一年[2021版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Geriatr, Wuhan, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Internal Med,Div Cardiol, Wuhan, Peoples R China

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