It is thought that a shallow invasion of the maternal decidua by extravillous trophohlasts (EVT) is associated with the development of pre-eclampsia. Here, we focus on the expression of the proangiogenic proteins Cyr61 and CTGF in the human placenta during normal pregnancy compared with that in the late pre-eclamptic placenta. Cyr61 and CTGF are expressed in the extravillous trophoblast and in endothelial cells. We found the expression of Cyr61 was significantly decreased in pre-eclamptic placentas compared with matched controls. In contrast, the CTGF expression level was upregulated in pre-eclamptic placentas. There was a negative correlation between Cyr61 and CTGF. These results suggest that decreased Cyr61 and overexpressed CTGF may play a part in the development of pre-eclampsia.
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan 430074, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Xi,Liu Yanyan,Xu Xiaoyan,et al.Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy[J].JOURNAL OF PERINATAL MEDICINE.2012,40(2):199-200.doi:10.1515/jpm-2011-0035.
APA：
Chen, Xi,Liu, Yanyan,Xu, Xiaoyan&Chen, Hanping.(2012).Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy.JOURNAL OF PERINATAL MEDICINE,40,(2)
MLA：
Chen, Xi,et al."Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy".JOURNAL OF PERINATAL MEDICINE 40..2(2012):199-200
