Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain, but the possible mechanism is poorly understood. Using a melanocortin-4 receptor (MC4R)-green fluorescent protein (GFP) reporter knockin mouse, we showed that a large number of MC4R-GFP-positive neurons were expressed in the cuneiform nucleus. Immunofluorescence revealed that approximately 40%-50% of MC4R-GFP-positive neurons expressed mu opioid receptors, indicating that they were opioidergic signaling. Our findings support the hypothesis that MC4R expression in the cuneiform nucleus is involved in the modulation of opioidergic signaling.
基金：
Health and Family Planning Commission of Hubei Province [WJ2015MB008]
第一作者单位：[1]Med Assoc Hubei Prov, Wuhan 430060, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Song Yong-tang,Liu Tao-tao,Feng Li,et al.Melanocortin-4 receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling[J].JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES.2015,35(5):662-665.doi:10.1007/s11596-015-1486-2.
APA：
Song, Yong-tang,Liu, Tao-tao,Feng, Li,Zhang, Tao&Xiang, Hong-bing.(2015).Melanocortin-4 receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling.JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES,35,(5)
MLA：
Song, Yong-tang,et al."Melanocortin-4 receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling".JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 35..5(2015):662-665
