This study was designed to assess whether MC4R signaling existed in vestibular nuclei modulated the activity of kidney by a virally mediated transsynaptic tracing study. Pseudorabies virus (PRV)-614 was injected into the kidney in adult male MC4R-green fluorescent protein (GFP) transgenic mice (n = 5). After a survival time of 5 days, the mice were assigned to humanely sacrifice, and the brainstem were removed and sectioned, and processed for PRV-614 visualization. The neurochemical phenotype of MC4R-GFP-positive neurons was identified using fluorescence immunocytochemical labeling. PRV-614/MC4R-GFP dual labeled neurons were detected in medial vestibular nuclei. Our findings support the hypothesis that there exist melanocortinergic circuits from medial vestibular nuclei to the kidney.
第一作者单位：[1]Huazhong Univ Sci & Technol Univ, Union Hosp, Tongji Med Coll, Dept Vasc Surg, Wuhan 430022, Peoples R China
通讯作者：
通讯机构：[3]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Anesthesiol & Pain Med, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China[*1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Anesthesiol & Pain Med, Tongji Med Coll, 1095 Jiefang Rd, Wuhan 430030, Hubei, Peoples R China
推荐引用方式(GB/T 7714)：
Shang Dan,Xiong Jun,Xiang Hong-Bing,et al.Melanocortinergic circuits from medial vestibular nuclei to the kidney defined by transneuronal transport of pseudorabies virus[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2015,8(2):1996-2000.
APA：
Shang, Dan,Xiong, Jun,Xiang, Hong-Bing,Hao, Yan&Liu, Jiu-Hong.(2015).Melanocortinergic circuits from medial vestibular nuclei to the kidney defined by transneuronal transport of pseudorabies virus.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,8,(2)
MLA：
Shang, Dan,et al."Melanocortinergic circuits from medial vestibular nuclei to the kidney defined by transneuronal transport of pseudorabies virus".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 8..2(2015):1996-2000
